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DOI 10.1038/s41467-026-68642-7

Медицинская библиотека · Nature communications · 2026

Multicountry genomic analysis underscores regional cholera spread in Africa.

Mboowa Gerald, Matteson Nathaniel Lucero, Tanui Collins Kipngetich, Kasonde Mpanga, Kamwiziku Guyguy Kusanzangana, Akanbi Olusola Anuoluwapo, Chitio Jucunú Johane Elias, Kagoli Mathews, Essomba René Ghislain, Ayitewala Alisen, Ssewanyana Isaac, Ngo Bitoungui Valentina Josiane, Amuri Adrienne Aziza, Azman Andrew S, Babatunde Olajumoke Atinuke, Akenji Blaise Mboringong, Broban Anaïs, Malembaka Espoir Bwenge, Ongole Francis, Chukwu Chimaobi Emmanuel, Ismael Nália, Kapona Otridah, Laurindo Osvaldo, Mbala Placide Kingebeni, Etoundi Mballa Georges Alain, Miambo Imelda Carlos Zulfa, Mwanyongo Alex Ansaye, Najjuka Grace, Mutale Joseph, Musonda Kunda, Niyonzima Allan Muruta, Nyenje Mirriam Ethel, Popoola Michael, Shempela Doreen Mainza, Sike Christiane Medi, Sitoe Sofião Manjor, Wanjohi Dorcas Waruguru, Welo Placide Okitayemba, Yelewa Mtisunge, Yennan Sebastian, Ziba Lucius, CholGEN Consortium, Bitilinyu-Bangoh Joseph Ephram, Chilengi Roma, Hadja Hamsatou, Idris Jide, Langa José Paulo Maurício, Mukadi-Bamuleka Daniel, Nabadda Susan, Debes Amanda K, Sack David A, Tebeje Yenew Kebede, Wohl Shirlee, Tessema Sofonias Kifle

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Аннотация

Cholera remains a significant public health burden in many countries in sub-Saharan Africa, though the exact mechanisms of bacterial emergence and spread remain largely undefined. We generated genomic data from 763 Vibrio cholerae O1 isolates predominantly collected between 2019-2024 to create the largest dataset of V. cholerae genomes sequenced locally in Africa. This dataset enabled us to interrogate recent patterns of spread, including the rapid circulation of the AFR15 lineage associated with unusually large outbreaks in Southern Africa. We provide evidence for the movement of the AFR15 lineage into new African Union Member States and confirm previously observed differences in V. cholerae transmission dynamics in West versus East Africa, though cross-border transmission is prevalent on both sides of the continent. Despite observed differences, evolutionary processes are similar across lineages and we find no evidence for significant changes in antimicrobial resistance genotypes. Overall, our findings emphasize the importance of regionally coordinated cross-border surveillance and interventions, while also demonstrating the critical role of locally generated genomic data in understanding the spread of cholera in Africa.

Для цитирования: Mboowa Gerald, Matteson Nathaniel Lucero, Tanui Collins Kipngetich, Kasonde Mpanga, Kamwiziku Guyguy Kusanzangana, Akanbi Olusola Anuoluwapo, Chitio Jucunú Johane Elias, Kagoli Mathews, Essomba René Ghislain, Ayitewala Alisen, Ssewanyana Isaac, Ngo Bitoungui Valentina Josiane, Amuri Adrienne Aziza, Azman Andrew S, Babatunde Olajumoke Atinuke, Akenji Blaise Mboringong, Broban Anaïs, Malembaka Espoir Bwenge, Ongole Francis, Chukwu Chimaobi Emmanuel, Ismael Nália, Kapona Otridah, Laurindo Osvaldo, Mbala Placide Kingebeni, Etoundi Mballa Georges Alain, Miambo Imelda Carlos Zulfa, Mwanyongo Alex Ansaye, Najjuka Grace, Mutale Joseph, Musonda Kunda, Niyonzima Allan Muruta, Nyenje Mirriam Ethel, Popoola Michael, Shempela Doreen Mainza, Sike Christiane Medi, Sitoe Sofião Manjor, Wanjohi Dorcas Waruguru, Welo Placide Okitayemba, Yelewa Mtisunge, Yennan Sebastian, Ziba Lucius, CholGEN Consortium, Bitilinyu-Bangoh Joseph Ephram, Chilengi Roma, Hadja Hamsatou, Idris Jide, Langa José Paulo Maurício, Mukadi-Bamuleka Daniel, Nabadda Susan, Debes Amanda K, Sack David A, Tebeje Yenew Kebede, Wohl Shirlee, Tessema Sofonias Kifle. Multicountry genomic analysis underscores regional cholera spread in Africa.. Nature communications. 2026. DOI: 10.1038/s41467-026-68642-7.

Предметные рубрики MeSH

CholeraGenome, BacterialHumansGenomicsVibrio cholerae O1AfricaPhylogenyDisease OutbreaksVibrio choleraeDrug Resistance, BacterialGenotype
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