International urology and nephrology · 2013
Procalcitonin: diagnostic value in systemic infections in chronic kidney disease or renal transplant patients.
СтатьяНаблюдательное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Dumea Raluca, Siriopol Dimitrie, Hogas Simona, Mititiuc Irina, Covic Adrian
Аннотация
PURPOSE: Although procalcitonin (PCT) has been described as a marker of infection and inflammation, it has not been extensively studied in patients with chronic kidney disease (CKD), end stage renal disease, or renal transplant.
METHODS: PCT was routinely tested in 82 (56 dialyzed patients and 28 renal transplant recipients) consecutive cases with a strong clinical suspicion of infection, during a 6-month period, in a single referral unit.
RESULTS: During the study period, 58/82 cases had confirmed infections as per definition. Patients with confirmed infections had higher values for PCT [median = 2.5 ng/mL, interquartile range (IR) = 0.9-5 ng/mL] than those without (median = 0.3 ng/mL, IR = 0.1-0.5 ng/mL), p < 0.001. Overall, for a cutoff value of 0.5 ng/mL, the sensitivity of the test was 93.1 % and the specificity 78.6.
CONCLUSION: Our data indicate that significantly elevated PCT concentrations offer good sensitivity and specificity for the early diagnosis of systemic bacterial infection in patients with CKD.
METHODS: PCT was routinely tested in 82 (56 dialyzed patients and 28 renal transplant recipients) consecutive cases with a strong clinical suspicion of infection, during a 6-month period, in a single referral unit.
RESULTS: During the study period, 58/82 cases had confirmed infections as per definition. Patients with confirmed infections had higher values for PCT [median = 2.5 ng/mL, interquartile range (IR) = 0.9-5 ng/mL] than those without (median = 0.3 ng/mL, IR = 0.1-0.5 ng/mL), p < 0.001. Overall, for a cutoff value of 0.5 ng/mL, the sensitivity of the test was 93.1 % and the specificity 78.6.
CONCLUSION: Our data indicate that significantly elevated PCT concentrations offer good sensitivity and specificity for the early diagnosis of systemic bacterial infection in patients with CKD.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overArea Under CurveArteriovenous Shunt, SurgicalBacteremiaBiomarkersC-Reactive ProteinCalcitoninCalcitonin Gene-Related PeptideEnterocolitisFemaleHumansKidney Failure, ChronicKidney TransplantationMaleMiddle AgedPeritoneal DialysisPeritonitisPneumonia, BacterialProtein PrecursorsPyelonephritisROC CurveYoung Adult