A comprehensive review of the role of LINC00462 in human disorders.

LINC00462; a long intergenic non-coding RNA located on chromosome chr13:48,576,973-48,590,587 is a member of long non-coding RNA (lncRNA) that is participated in different human disorders such as pancreatic cancer and hepatocellular carcinoma. LINC00462 can act as competing endogenous RNAs (ceRNAs), to sponge different MicroRNAs (miRNAs) such as miR-665. Dysregulation of LINC00462 can promote cancer development, progression, and metastasis. LINC00462 can also bind directly with genes and proteins to regulate different pathways, including STAT2/3 and PI3K/AKT pathways to affected tumor progression. In addition, aberrant LINC00462 levels can be important cancer-specific prognostic and diagnostic markers. In this review, we summarize the most recent studies on the role of LINC00462 in different disorders and demonstrated the role of LINC00462 in tumorigenesis.