Tamoxifen induced endometrial abnormalities: evaluation by saline infusion sonohysterography.

Patients receiving tamoxifen therapy for breast cancer are at an increased risk for endometrial hyperplasia, polyps, and adenocarcinoma. Therefore, any bleeding in the post-menopausal patient on tamoxifen warrants further investigation. Sonohysterography is a new technique for evaluating the uterine cavity and clarifying the location of endometrial and peri-endometrial processes. Differentiating subendometrial cyst formation from endometrial proliferation can save patients from further, invasive investigative diagnostic procedures.