Journal of magnetic resonance imaging : JMRI · 2011
Polydisulfide manganese(II) complexes as non-gadolinium biodegradable macromolecular MRI contrast agents.
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Ye Zhen, Jeong Eun-Kee, Wu Xueming, Tan Mingqian, Yin Shouyu, Lu Zheng-Rong
Аннотация
PURPOSE: To develop safe and effective manganese(II) -based biodegradable macromolecular MRI contrast agents.
MATERIALS AND METHODS: In this study, we synthesized and characterized two polydisulfide manganese(II) complexes, Mn-DTPA cystamine copolymers and Mn-EDTA cystamine copolymers, as new biodegradable macromolecular MRI contrast agents. The contrast enhancement of the two manganese-based contrast agents were evaluated in mice bearing MDA-MB-231 human breast carcinoma xenografts, in comparison with MnCl(2) .
RESULTS: The T(1) and T(2) relaxivities were 4.74 and 10.38 mM(-1) s(-1) per manganese at 3T for Mn-DTPA cystamine copolymers (M(n) = 30.50 kDa) and 6.41 and 9.72 mM(-1) s(-1) for Mn-EDTA cystamine copolymers (M(n) = 61.80 kDa). Both polydisulfide Mn(II) complexes showed significant liver, myocardium and tumor enhancement.
CONCLUSION: The manganese-based polydisulfide contrast agents have a potential to be developed as alternative non-gadolinium contrast agents for MR cancer and myocardium imaging.
MATERIALS AND METHODS: In this study, we synthesized and characterized two polydisulfide manganese(II) complexes, Mn-DTPA cystamine copolymers and Mn-EDTA cystamine copolymers, as new biodegradable macromolecular MRI contrast agents. The contrast enhancement of the two manganese-based contrast agents were evaluated in mice bearing MDA-MB-231 human breast carcinoma xenografts, in comparison with MnCl(2) .
RESULTS: The T(1) and T(2) relaxivities were 4.74 and 10.38 mM(-1) s(-1) per manganese at 3T for Mn-DTPA cystamine copolymers (M(n) = 30.50 kDa) and 6.41 and 9.72 mM(-1) s(-1) for Mn-EDTA cystamine copolymers (M(n) = 61.80 kDa). Both polydisulfide Mn(II) complexes showed significant liver, myocardium and tumor enhancement.
CONCLUSION: The manganese-based polydisulfide contrast agents have a potential to be developed as alternative non-gadolinium contrast agents for MR cancer and myocardium imaging.