Journal of chemotherapy (Florence, Italy) · 2014
Does topical voriconazole trigger dysplastic changes on the ocular surface?
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Palamar Melis, Egrilmez Sait, Yilmaz Suzan Guven, Polat Suleyha Hilmioglu, Gunduz Omur Ucakhan
Аннотация
PURPOSE: Systemic voriconazole treatment was reported to cause photosensitivity and related cutaneous malignancies. The aim of this report is to demonstrate a graft-related Candida endophthalmitis case that developed ocular surface dysplastic changes after receiving topical 1% voriconazole treatment.
METHODS: Full ocular examination, photography, and in vivo confocal microscopy examination (Rostock Cornea Module/HRT II, Heidelberg, Germany) were performed.
RESULTS: A 73-year-old male with graft-related Candida endophthalmitis that was on topical 1% voriconazole for 4 months developed a whitish gelatinous lesion on the cornea originating from the nasal limbus. In vivo confocal microscopy examination revealed mild dysplastic changes in the cornea epithelium.
CONCLUSION: Topical voriconazole might trigger neoplastic changes on the ocular surface as reported with systemic use in other sun-exposed parts of the body. Further studies are needed to relate topical use of voriconazole with ocular surface dysplasia.
METHODS: Full ocular examination, photography, and in vivo confocal microscopy examination (Rostock Cornea Module/HRT II, Heidelberg, Germany) were performed.
RESULTS: A 73-year-old male with graft-related Candida endophthalmitis that was on topical 1% voriconazole for 4 months developed a whitish gelatinous lesion on the cornea originating from the nasal limbus. In vivo confocal microscopy examination revealed mild dysplastic changes in the cornea epithelium.
CONCLUSION: Topical voriconazole might trigger neoplastic changes on the ocular surface as reported with systemic use in other sun-exposed parts of the body. Further studies are needed to relate topical use of voriconazole with ocular surface dysplasia.
Предметные рубрики MeSH
Administration, OphthalmicAgedAntifungal AgentsCandidaCandidiasisCorneaCorneal DiseasesCorneal OpacityDiagnosis, DifferentialEndophthalmitisEye NeoplasmsHumansInjections, IntraocularIntravitreal InjectionsMaleMicroscopy, ConfocalNeoplasms, Squamous CellOphthalmic SolutionsPrecancerous ConditionsTreatment OutcomeVoriconazole