Frontiers in immunology · 2025
Multiomics analysis unveils key biomarkers during dynamic progress of IAV infection in mice.
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Lei Huan, Xu Yixi, Zhang Hao, Zhang Bin, Luo Wenjun, Liu Xiao, Zhang Haijun, Yang Jinming, Wen Wen, Wang Ping, Xu Shijun
Аннотация
INTRODUCTION: Influenza infection is a significant threat to public health, and identifying dynamic biomarkers that influence disease progression is crucial for effective intervention.
METHODS: We conducted a comprehensive evaluation of physiological and pathological parameters in Balb/c mice infected with H1N1 influenza over a 14-day period. We employed the DIABLO multi-omics integration method to analyze dynamic changes in the lung transcriptome, metabolome, and serum metabolome from mild to severe stages of infection.
RESULTS: Our analysis highlighted the critical importance of intervention within the first 6 days post-infection to prevent severe disease. We identified several novel biomarkers associated with disease progression, including Ccl8, Pdcd1, Gzmk, kynurenine, L-glutamine, and adipoyl-carnitine. Additionally, we developed a serum-based influenza disease progression scoring system.
DISCUSSION: This study provides new insights into the molecular mechanisms underlying influenza progression and identifies potential targets for therapeutic intervention. The developed scoring system serves as a valuable tool for early diagnosis and prognosis of severe influenza.
METHODS: We conducted a comprehensive evaluation of physiological and pathological parameters in Balb/c mice infected with H1N1 influenza over a 14-day period. We employed the DIABLO multi-omics integration method to analyze dynamic changes in the lung transcriptome, metabolome, and serum metabolome from mild to severe stages of infection.
RESULTS: Our analysis highlighted the critical importance of intervention within the first 6 days post-infection to prevent severe disease. We identified several novel biomarkers associated with disease progression, including Ccl8, Pdcd1, Gzmk, kynurenine, L-glutamine, and adipoyl-carnitine. Additionally, we developed a serum-based influenza disease progression scoring system.
DISCUSSION: This study provides new insights into the molecular mechanisms underlying influenza progression and identifies potential targets for therapeutic intervention. The developed scoring system serves as a valuable tool for early diagnosis and prognosis of severe influenza.