Leptols A and B, one meroterpenoid and one coumarin hybrid from the leaves of Melicope pteleifolia and its anti-inflammation in BV2 cells.

One meroterpenoid and one coumarin hybrid, namely leptols A (1) and B (2), respectively, and seven known chromone analogues have been isolated from the leaves of Melicope pteleifolia. The structures were elucidated on the basis of spectroscopic methods (UV, IR, HRMS, and NMR), and the absolute configuration was determined by comparing its experimental and calculated OR values. These isolates were evaluated for anti-inflammatory activities on the lipopolysaccharide (LPS) induced nitric oxide (NO) production in BV2 microglial cells, and compound 1 exhibited potential nitric oxide inhibitory activities with IC50 value of 12.0 µM.