Some pharmacological properties of a novel series of 2-substituted 2-phenylcyclohexyl N,N-diethylaminoethyl ethers. II.

The second of a series of 2-phenylcyclohexyl N,N-diethylaminoethyl ethers, (trans-compound), was investigated for its pharmacological actions in mice and rats. The trans-compound shortened the duration of methacholine (20 mg/kg)-induced salivation in mice, which was observed to be inversely proportional to the intraperitoneally administered dose of the compound. In anesthetized rats, a time-course study revealed the effects of the compound to be brief (5-15 minutes). When administered alone, it decreased heart rate, systolic, diastolic and mean arterial pressures and increased pulse-pressure. It produced transient apnea followed by slight increase in respiration. In other anesthetized rats, pretreatment with 5 mg/kg trans-compound reversed the depression response and bradycardia induced by injection of increasing doses of methacholine. Respiratory rate was similarly decreased due to initial transient apnea followed by a slight increase. There was a non-significant decrease in rectal temperature when methacholine was injected before or after the compound. These experiments suggest that the trans-compound possesses a weaker anticholinergic activity compared to the cis-compound.