Identifying the Hiccup-Induced Esophagogastric Waveform: A Case Series Report Using High-Resolution Manometry.

Hiccups result from involuntary contractions of the diaphragm, driven by a complex neuromuscular reflex. Three patients with persistent hiccups underwent esophageal high-resolution manometry during hiccup episodes, revealing a consistent finding: sustained contraction of the esophagogastric junction with intermittent pressure peaks. This pattern, termed the "Hiccup-Induced Esophagogastric Waveform," shows significant esophageal pressure changes linked to hiccup reflex. It may reflect a compensatory mechanism to expel excess esophageal residue or gas. These findings suggest hiccups could exacerbate symptoms of esophageal disorders, such as dysphagia and chest pain, and highlight the need for targeted therapeutic strategies. Further research is needed to explore these mechanisms.