Fertility and sterility · 1997
Congenital absence of the uterus and vagina is not commonly transmitted as a dominant genetic trait: outcomes of surrogate pregnancies.
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Petrozza J C, Gray M R, Davis A J, Reindollar R H
Аннотация
OBJECTIVE: To determine the inheritance pattern of congenital absence of the uterus and vagina in affected women undergoing surrogacy IVF with this disorder.
DESIGN: Retrospective study.
SETTING: A hospital-based reproductive endocrinology and infertility center.
PATIENT(S): Women diagnosed with congenital absence of the uterus and vagina undergoing IVF with subsequent transfer of embryos to a surrogate uterus.
INTERVENTION(S): Questionnaires were sent to all infertility treatment centers performing surrogate procedures.
MAIN OUTCOME MEASURE(S): Number, gender, and frequency of congenital anomalies in progeny.
RESULT(S): Thirty-two of 53 surveyed programs responded (60%). One hundred sixty-two IVF cycles were performed, and 34 liveborn children were delivered (half female). No congenital anomalies were found, except for one male child with a middle ear defect and hearing loss.
CONCLUSION(S): These results strongly suggest that congenital absence of the uterus and vagina, if genetically transmitted, is not inherited commonly in a dominant fashion.
DESIGN: Retrospective study.
SETTING: A hospital-based reproductive endocrinology and infertility center.
PATIENT(S): Women diagnosed with congenital absence of the uterus and vagina undergoing IVF with subsequent transfer of embryos to a surrogate uterus.
INTERVENTION(S): Questionnaires were sent to all infertility treatment centers performing surrogate procedures.
MAIN OUTCOME MEASURE(S): Number, gender, and frequency of congenital anomalies in progeny.
RESULT(S): Thirty-two of 53 surveyed programs responded (60%). One hundred sixty-two IVF cycles were performed, and 34 liveborn children were delivered (half female). No congenital anomalies were found, except for one male child with a middle ear defect and hearing loss.
CONCLUSION(S): These results strongly suggest that congenital absence of the uterus and vagina, if genetically transmitted, is not inherited commonly in a dominant fashion.