iScience · 2023
Proteogenomic landscape of gastric adenocarcinoma peritoneal metastases.
СтатьяНазвание и аннотация: Перевод в очереди
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Zhao Shuangtao, Wang Ruiping, Song Shumei, Hao Dapeng, Han Guangchun, Song Xingzhi, Zhang Jianhua, Pizzi Melissa Pool, Shanbhag Namita, Futreal Andrew, Badgwell Brian, Harada Kazuto, Calin George, Vykoukal Jody, Yu Chuan-Yih, Katayama Hiroyuki, Hanash Samir M, Wang Linghua, Ajani Jaffer A
Аннотация
Advanced gastric adenocarcinoma (GAC) often leads to peritoneal carcinomatosis (PC) and is associated with very poor outcome. Here we report the comprehensive proteogenomic study of ascites derived cells from a prospective GAC cohort (n = 26 patients with peritoneal carcinomatosis, PC). A total of 16,449 proteins were detected from whole cell extracts (TCEs). Unsupervised hierarchical clustering resulted in three distinct groups that reflected extent of enrichment in tumor cells. Integrated analysis revealed enriched biological pathways and notably, some druggable targets (cancer-testis antigens, kinases, and receptors) that could be exploited to develop effective therapies and/or tumor stratifications. Systematic comparison of expression levels of proteins and mRNAs revealed special expression patterns of key therapeutics target notably high mRNA and low protein expression of HAVCR2 (TIM-3), and low mRNA but high protein expression of cancer-testis antigens CTAGE1 and CTNNA2. These results inform strategies to target GAC vulnerabilities.