Medicine · 2024
Late onset neonatal sepsis: Can plasma gelsolin be a promising diagnostic marker?
СтатьяНазвание и аннотация: Перевод в очереди
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Mokhtar Wesam A, Sherief Laila M, Kamal Naglaa M, ElSheikh Azza O, Omran Farida H, Abdulsaboor Ahmed, Sakr Maha M H, El Gebally Shreif, Shehab Mohamed M M, Alfaifi Jaber, Turkistani Reem, Aljuaid Futun, Oshi Mohammed A M, Elbekoushi Fouad B A, Mokhtar Ghada A
Аннотация
Plasma gelsolin (pGSN) correlates with clinical improvement in septic patients. We aimed to investigate pGSN levels as a diagnostic and prognostic marker of neonatal late-onset-sepsis (LOS). A case-control study was done on 184 neonates (92 with LOS and 92 controls). All participants were subjected to detailed history taking, full clinical evaluation, sepsis workup, and pGSN enzyme-linked immunosorbent-assay measurement. We detected significantly lower pGSN level among cases compared to controls (90.63 ± 20.64 vs 451.83 ± 209.59). It was significantly related to the severity of sepsis and mortality, with significantly lower values among cases with septic shock and multiorgan failure and non-survivors. Follow-up pGSN significantly increased after sepsis improvement in survivors compared to admission values. pGSN might be a reliable diagnostic and prognostic marker for LOS.