Medicina clinica · 2026
Clinical implications of cardiac involvement in Q fever: Findings from a Spanish cohort.
СтатьяНазвание и аннотация: Перевод в очереди
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de la Guía Ester Mínguez, Vázquez Macarena López, Sancho Jose Javier Blanch, Córdoba Raúl Calvo, Martínez Francisco Manuel Salmeron, Pascual Miguel Corbí
Аннотация
INTRODUCTION: Q fever is a zoonosis caused by Coxiella burnetii. Spain reports the highest incidence in Europe. Its chronic form may present as infective endocarditis, though other cardiac complications have also been described.
METHODS: We conducted a retrospective study of patients admitted for Q fever at a tertiary hospital between 2000 and 2023. Only microbiologically confirmed cases were included. Clinical presentation was analyzed, focusing on patients with cardiac involvement.
RESULTS: A total of 42 patients were included (66.6% male, mean age 49.7±20.6 years); 28 (66.7%) had acute Q fever and 14 (33.3%) chronic. Cardiac involvement was identified in 12 patients (28.5%): 7 with infective endocarditis (all chronic), 3 with myocarditis (2 progressed to dilated cardiomyopathy), and 2 with pericarditis. Overall mortality among patients with cardiac involvement was 25%.
CONCLUSION: Cardiac manifestations in Q fever may be underdiagnosed. In our cohort, cardiac involvement was frequent and associated with high mortality. Clinicians should maintain a high index of suspicion, especially in chronic Q fever or in patients with fever of unknown origin.
METHODS: We conducted a retrospective study of patients admitted for Q fever at a tertiary hospital between 2000 and 2023. Only microbiologically confirmed cases were included. Clinical presentation was analyzed, focusing on patients with cardiac involvement.
RESULTS: A total of 42 patients were included (66.6% male, mean age 49.7±20.6 years); 28 (66.7%) had acute Q fever and 14 (33.3%) chronic. Cardiac involvement was identified in 12 patients (28.5%): 7 with infective endocarditis (all chronic), 3 with myocarditis (2 progressed to dilated cardiomyopathy), and 2 with pericarditis. Overall mortality among patients with cardiac involvement was 25%.
CONCLUSION: Cardiac manifestations in Q fever may be underdiagnosed. In our cohort, cardiac involvement was frequent and associated with high mortality. Clinicians should maintain a high index of suspicion, especially in chronic Q fever or in patients with fever of unknown origin.