Internal medicine (Tokyo, Japan) · 2013
Infective endocarditis caused by Enterococcus faecalis treated with continuous infusion of ampicillin without adjunctive aminoglycosides.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Ogawa Taku, Sato Masatoshi, Yonekawa Shinsuke, Nakagawa Chiyo, Uno Kenji, Kasahara Kei, Maeda Koichi, Konishi Mitsuru, Mikasa Keiichi
Аннотация
Aminoglycosides are useful antimicrobial agents for treating infective endocarditis; however, they occasionally cause troublesome side effects, such as nephrotoxicity and ototoxicity. We herein report a case of infective endocarditis caused by Enterococcus faecalis that was treated successfully with continuous infusion of ampicillin without adjunctive aminoglycosides. The serum ampicillin concentrations were higher than the minimal inhibitory concentration for the target strain. Although the use of ampicillin monotherapy is currently avoided because double β-lactam therapy is reportedly more effective, continuous penicillin administration remains an effective therapeutic choice for treating infective endocarditis.
Предметные рубрики MeSH
AgedAminoglycosidesAmpicillinAnti-Bacterial AgentsAnticoagulantsArthroplasty, Replacement, HipAtrial FibrillationContraindicationsDiagnosis, DifferentialEndocarditis, BacterialEnterococcus faecalisFemoral Neck FracturesGram-Positive Bacterial InfectionsHumansInfusions, IntravenousMaleMicrobial Sensitivity TestsMitral ValvePostoperative ComplicationsPractice Guidelines as TopicPyelonephritisStreptomycinWarfarin