[Effects of prenatal alcohol exposure on auditory brainstem response in rats].

OBJECTIVE

To study the effects of prenatal alcohol exposure, with an animal model of auditory brainstem response recorded in the conditions of various alcohol dosages administrated during embryonic period, on auditory nervous system in rats.

METHOD: Normal female rats were divided into 2 groups. From the days 8.5 after mating, pregnant rats were fed 50% analytical reagent alcohol via intragastric administration with 2.0 and 1.0 g/(kg x d) respectively in consecutive 6 days. On the days 40 after birth, ABR was recorded in young rats under anesthesia. Normal young rats with parallel age were chosen as the normal group.

RESULT: Prenatal alcohol exposure had effects on ABR, manifesting the incidence rate of I wave lowing (14%, 30%), latency delaying (P<0.05) and amplitude reducing.

CONCLUSION

Prenatal alcohol exposure had conspicuous effects on auditory nervous system in rats, by step down nerve impulse conduction.