Archives of pediatrics & adolescent medicine · 1999
Neonatal jaundice and diet.
Клиническое исследованиеСравнительное исследованиеСтатьяРандомизированное исследованиеПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Gourley G R, Kreamer B, Cohnen M, Kosorok M R
Аннотация
OBJECTIVE: To determine whether an earlier observation, that infants fed a casein-hydrolysate formula (Nutramigen) have lower neonatal jaundice levels than those fed standard formulas, would be repeated in a larger independent group of infants with more frequent measurements and more rigorous statistical analysis.
DESIGN: Newborn infants were fed human milk, a standard whey-predominant formula (Enfamil), or Nutramigen (n = 20 for each group) during the first 3 weeks of life. Transcutaneous jaundice index was measured daily for the first week of life and every 2 to 3 days thereafter, using a noninvasive jaundice meter. Linear regression models of the data were constructed, validated, and compared statistically.
SETTING: General community hospital with subsequent home visitation.
PARTICIPANTS: Healthy, term newborn infants selected by convenience, based on time of birth.
INTERVENTION: Infants were exclusively fed human milk, Enfamil, or Nutramigen. Formulas were randomly assigned.
MAIN OUTCOME MEASURE: Jaundice index, a transcutaneous measurement of jaundice.
RESULTS: The jaundice index differed significantly among the 3 groups. Paired comparisons showed that the jaundice index of the Nutramigen group was significantly lower than that of the Enfamil group (on days 6-16) and the human milk group (on days 3-20). The jaundice index of the Enfamil-fed group was significantly lower than that of the human milk group on days 13 to 19.
CONCLUSIONS: Jaundice levels are lower in neonates fed Nutramigen rather than Enfamil and both these groups have lower jaundice levels than breast-fed infants.
DESIGN: Newborn infants were fed human milk, a standard whey-predominant formula (Enfamil), or Nutramigen (n = 20 for each group) during the first 3 weeks of life. Transcutaneous jaundice index was measured daily for the first week of life and every 2 to 3 days thereafter, using a noninvasive jaundice meter. Linear regression models of the data were constructed, validated, and compared statistically.
SETTING: General community hospital with subsequent home visitation.
PARTICIPANTS: Healthy, term newborn infants selected by convenience, based on time of birth.
INTERVENTION: Infants were exclusively fed human milk, Enfamil, or Nutramigen. Formulas were randomly assigned.
MAIN OUTCOME MEASURE: Jaundice index, a transcutaneous measurement of jaundice.
RESULTS: The jaundice index differed significantly among the 3 groups. Paired comparisons showed that the jaundice index of the Nutramigen group was significantly lower than that of the Enfamil group (on days 6-16) and the human milk group (on days 3-20). The jaundice index of the Enfamil-fed group was significantly lower than that of the human milk group on days 13 to 19.
CONCLUSIONS: Jaundice levels are lower in neonates fed Nutramigen rather than Enfamil and both these groups have lower jaundice levels than breast-fed infants.