Comparative immunology, microbiology and infectious diseases · 2019
Progenitor mast cells and tryptase in Q fever.
СтатьяНазвание и аннотация: Перевод в очереди
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Mezouar Soraya, Morel Victor, Leveille Laury, Resseguier Noémie, Chartier Céline, Raoult Didier, Mege Jean-Louis, Vitte Joana
Аннотация
Q fever is an infectious disease due to Coxiella burnetii. Following a primary-infection, C. burnetii may persist in some patients, leading to endocarditis and vascular infections. Mast cells (MCs), known for their role in allergic diseases, innate immunity and cardiac function, are produced by bone marrow, circulate as progenitors in the bloodstream and reach tissues for their maturation and activation. The latter may be estimated by measuring serum tryptase levels. We wondered if MC progenitors and tryptase were affected in Q fever. We showed a decrease in MC progenitor count in Q fever patients whereas serum tryptase levels were increased. Taken together, our results show alterations of MC numbers and activity in Q fever patients, suggesting that MC are involved in Q fever pathophysiology.