American journal of obstetrics and gynecology · 1993
Effects of hydralazine on pregnant rats and their fetuses.
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Pryde P G, Abel E L, Hannigan J, Evans M I, Cotton D B
Аннотация
OBJECTIVE: We conducted this study to assess potential teratogenic or fetotoxic effects of in utero hydralazine exposure in the rat.
STUDY DESIGN: Pregnant rats were treated with hydralazine (0, 15, or 30 mg/kg/day) by either gavage or subcutaneous injection during gestation days 8 through 19, inclusively. Surviving animals were killed, uterine contents examined, and fetuses evaluated by Wilson's method for teratologic examination.
RESULTS: Oral administration did not affect maternal weight gain or fetal or placental weights. Subcutaneous administration decreased fetal and placental weights but only in dams given the highest dose subcutaneously; significantly increased maternal mortality and reduced maternal weight gain were also observed. There was no increased incidence of fetal anomalies in any group.
CONCLUSION: Hydralazine does not have teratogenic or fetopathic effects when given to rats in dosages that are nontoxic to the mother.
STUDY DESIGN: Pregnant rats were treated with hydralazine (0, 15, or 30 mg/kg/day) by either gavage or subcutaneous injection during gestation days 8 through 19, inclusively. Surviving animals were killed, uterine contents examined, and fetuses evaluated by Wilson's method for teratologic examination.
RESULTS: Oral administration did not affect maternal weight gain or fetal or placental weights. Subcutaneous administration decreased fetal and placental weights but only in dams given the highest dose subcutaneously; significantly increased maternal mortality and reduced maternal weight gain were also observed. There was no increased incidence of fetal anomalies in any group.
CONCLUSION: Hydralazine does not have teratogenic or fetopathic effects when given to rats in dosages that are nontoxic to the mother.