Медицинская библиотека · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2014

Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants.

Pelizzo Gloria, Mimmi Maria Chiara, Ballico Maurizio, Marotta Mario, Goruppi Ilaria, Peiro Jose Louis, Zambaiti Elisa, Costanzo Federico, Andreatta Erika, Tonin Elena, Calcaterra Valeria

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Аннотация

BACKGROUND

The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.

METHODS

Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution (1)H NMR-spectroscopy.

RESULTS

Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.

CONCLUSIONS

Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.

Для цитирования: Pelizzo Gloria, Mimmi Maria Chiara, Ballico Maurizio, Marotta Mario, Goruppi Ilaria, Peiro Jose Louis, Zambaiti Elisa, Costanzo Federico, Andreatta Erika, Tonin Elena, Calcaterra Valeria. Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants.. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2014. DOI: 10.3109/14767058.2014.991708.

Предметные рубрики MeSH

Humans Infant Infant, Newborn Lung Male Metabolome Phenotype Respiratory System Abnormalities

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