[Treatment of tubal ectopic pregnancy by methotrexate].

OBJECTIVES

To make a literature analyse about methotrexate as a treatment of tubal ectopic pregnancy.

MATERIALS AND

METHODS

We made a PubMed research and found articles, randomized control studies, systematic revues and meta-analyses of the Cochrane Database about ectopic pregnancies treated by methotrexate. We made a summary of these articles.

RESULTS

Methotrexate can be used as a treatment of tubal ectopic pregnancy with hCG<5000 UI/L and expectative is an option if hCG level is lower than 1500 UI/L. Medical treatment by methotrexate seems to be less effective than surgical salpingotomy but the rate of recurrence and the rate of intra-uterine pregnancy are similar regardless of the treatment chosen. Fertility seems to be the same after treatment by methotrexate. Economically, methotrexate is less expensive than the surgical management (laparoscopy).

CONCLUSION

Methotrexate can be used as a treatment of tubal ectopic pregnancies if every criterions of safety are gathered.