China CDC weekly · 2026
Genetic Analysis of Coxsackievirus A4 Among Healthy Children - Xizang Autonomous Region, China, 1996-2024.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Xiao Kaitao, Hong Mei, Xiao Mengyi, Li Fan, Shao Kexin, Zhu Chenglin, Yang Lan, Lin Jie, Wang Qin, Zhuoga Cidan, Zhu Shuangli, Yan Dongmei, Zhang Yong, Li Xiaomei, Xiao Jinbo
Аннотация
INTRODUCTION: Coxsackievirus A4 (CVA4) causes several diseases, including hand, foot, and mouth disease (HFMD) and herpangina. This study analyzed CVA4 isolates collected between 1996 and 2024 from the Xizang Autonomous Region to elucidate the phylogenetic characteristics and epidemiological patterns of this virus in high-altitude regions.
METHODS: VP1 coding region sequences of CVA4 were obtained through virus isolation and Sanger sequencing. MEGA software was used to construct a maximum likelihood phylogenetic tree based on the VP1 region. The BEAST toolkit was used to generate a maximum clade credibility tree and perform phylogeographic analysis.
RESULTS: From 2018 onwards, the prevalence of CVA4 among healthy carriers increased significantly, accounting for 62.12% of all detections. Genotyping revealed that most isolates belonged to genotype C, while the remainder were classified as D2. As the dominant genotype, genotype C has spread outward from Xigaze and Lhasa since 2011, leading to multiple asymptomatic infections in Shannan (2020), Xigaze and Lhasa (2023), and Ngari Prefecture (2024).
CONCLUSIONS: Transmission of CVA4 genotype C among healthy children in high-altitude areas suggests strong environmental adaptability, highlighting the need to strengthen enterovirus surveillance and control, including targeted monitoring of CVA4, in these regions.
METHODS: VP1 coding region sequences of CVA4 were obtained through virus isolation and Sanger sequencing. MEGA software was used to construct a maximum likelihood phylogenetic tree based on the VP1 region. The BEAST toolkit was used to generate a maximum clade credibility tree and perform phylogeographic analysis.
RESULTS: From 2018 onwards, the prevalence of CVA4 among healthy carriers increased significantly, accounting for 62.12% of all detections. Genotyping revealed that most isolates belonged to genotype C, while the remainder were classified as D2. As the dominant genotype, genotype C has spread outward from Xigaze and Lhasa since 2011, leading to multiple asymptomatic infections in Shannan (2020), Xigaze and Lhasa (2023), and Ngari Prefecture (2024).
CONCLUSIONS: Transmission of CVA4 genotype C among healthy children in high-altitude areas suggests strong environmental adaptability, highlighting the need to strengthen enterovirus surveillance and control, including targeted monitoring of CVA4, in these regions.