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DOI 10.1038/s43587-025-01061-3

Медицинская библиотека · Nature aging · 2026

Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America.

Caviedes Ariel, Cabral-Miranda Felipe, Orellana Paulina, Hernández Hernán, Henríquez Fernando, Gonzalez-Gomez Raul, Pizarro Matias, Migeot Joaquin, Ochoa-Rosales Carolina, Gonzalez-Silva Carolina, Marin-Diaz Nickole, Coronel-Oliveros Carlos, Santamaría-García Hernando, Carmona Danilo, García Adolfo M, Slachevsky Andrea, Singleton Andrew, Qi Andy Yue, Lawlor Brian, Miller Bruce, Dhooge Catherine, Pantazis Caroline, Udeh-Momoh Chinedu T, Aguillón David, Matallana Diana L, Zimmer Eduardo R, Resende Elisa de Paula França, Farina Francesca R, Cabello Francisca, Lopera Francisco, Zetterberg Henrik, Avila-Funes José Alberto, Acosta-Uribe Juliana, Possin Katherine L, Kosik Kenneth S, Hu Kun, Takada Leonel T, de Oliveira Maira Okada, Maito Marcelo Adrian, Suárez-Calvet Marc, Godoy Maria E, Behrens Maria Isabel, Parra Mario A, Del Campo Marta, Bruno Martin, Gelvez Nancy, Pozo-Castro Natalia, Cochran J Nicholas, Custodio Nilton, Ortega Rodrigo, Santibanez Rodrigo, de la Cruz Rolando, Montesinos Rosa, McDonagh Sarah, Bandres-Ciga Sara, Javandel Shireen, Brucki Sonia M D, Pina-Escudero Stefanie D, Valcour Victor, Li Ziyi, Yokoyama Jennifer S, Ibañez Agustin, Duran-Aniotz Claudia, Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat)

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Аннотация

Dementia diagnosis increasingly relies on blood-based biomarkers, yet their performance in diverse populations remains insufficiently characterized. Latin America, with substantial genetic and environmental heterogeneity, is particularly underrepresented in biomarker research. Here we show that plasma AT(N) biomarkers can distinguish Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) in a multinational Latin American cohort (N = 605). Aβ42/Aβ40 amyloid-β ratios were reduced and levels of phosphorylated tau (p-tau217, p-tau181) and neurofilament light chain (NfL) were elevated in both disorders, with NfL showing greater increases in FTLD. Classification models achieved receiver operating characteristic areas under the curve (ROC AUCs) of 83% for AD and 88% for FTLD. Meta-analyses confirmed consistency across countries, and these markers correlated with executive, memory and global cognitive impairment. Biomarker alterations combined with disease-specific neuroimaging patterns and cognitive measures further improved accuracy (ROC AUCs of 89% for AD and 95% for FTLD). These findings indicate that plasma AT(N) biomarkers, combined with neuroimaging and clinical assessments, can enhance dementia diagnosis across diverse Latin American populations.

Для цитирования: Caviedes Ariel, Cabral-Miranda Felipe, Orellana Paulina, Hernández Hernán, Henríquez Fernando, Gonzalez-Gomez Raul, Pizarro Matias, Migeot Joaquin, Ochoa-Rosales Carolina, Gonzalez-Silva Carolina, Marin-Diaz Nickole, Coronel-Oliveros Carlos, Santamaría-García Hernando, Carmona Danilo, García Adolfo M, Slachevsky Andrea, Singleton Andrew, Qi Andy Yue, Lawlor Brian, Miller Bruce, Dhooge Catherine, Pantazis Caroline, Udeh-Momoh Chinedu T, Aguillón David, Matallana Diana L, Zimmer Eduardo R, Resende Elisa de Paula França, Farina Francesca R, Cabello Francisca, Lopera Francisco, Zetterberg Henrik, Avila-Funes José Alberto, Acosta-Uribe Juliana, Possin Katherine L, Kosik Kenneth S, Hu Kun, Takada Leonel T, de Oliveira Maira Okada, Maito Marcelo Adrian, Suárez-Calvet Marc, Godoy Maria E, Behrens Maria Isabel, Parra Mario A, Del Campo Marta, Bruno Martin, Gelvez Nancy, Pozo-Castro Natalia, Cochran J Nicholas, Custodio Nilton, Ortega Rodrigo, Santibanez Rodrigo, de la Cruz Rolando, Montesinos Rosa, McDonagh Sarah, Bandres-Ciga Sara, Javandel Shireen, Brucki Sonia M D, Pina-Escudero Stefanie D, Valcour Victor, Li Ziyi, Yokoyama Jennifer S, Ibañez Agustin, Duran-Aniotz Claudia, Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat). Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America.. Nature aging. 2026. DOI: 10.1038/s43587-025-01061-3.

Предметные рубрики MeSH

HumansFrontotemporal Lobar DegenerationAlzheimer DiseaseBiomarkersLatin Americatau ProteinsFemaleAmyloid beta-PeptidesMaleNeurofilament ProteinsAgedMiddle AgedPeptide FragmentsROC Curve
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