The Journal of pathology · 1992
The erbB-3 gene in human pancreatic cancer.
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Lemoine N R, Lobresco M, Leung H, Barton C, Hughes C M, Prigent S A, Gullick W J, Klöppel G
Аннотация
Abnormalities of the type 1 growth factor receptor family have been implicated in the pathogenesis of pancreatic cancer. There is evidence for a potential autocrine loop involving overexpression of the epidermal growth factor (EGF) receptor and its ligands, as well as overexpression of the erbB-2 receptor. A third member of this receptor family, erbB-3, has recently been recognized and found to be abnormally expressed in some types of human cancer. In this study we show that overexpression of the erbB-3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis. We found no evidence of amplification or rearrangement of the erbB-3 gene by Southern blot analysis of DNA from pancreatic cancer cells lines.
Предметные рубрики MeSH
Amino Acid SequenceBlotting, SouthernCell LineChronic DiseaseErbB ReceptorsGene AmplificationGene ExpressionGene RearrangementHumansImmunohistochemistryMolecular Sequence DataOncogene Proteins v-erbBPancreasPancreatic NeoplasmsPancreatitisProto-Oncogene ProteinsReceptor, ErbB-3Retroviridae Proteins, Oncogenic