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DOI 10.3390/ph19040586

Медицинская библиотека · Pharmaceuticals (Basel, Switzerland) · 2026

The Role of an Herbal Preparation in Enhancing the Efficacy of Basic Therapy in Patients with Periodontitis: Evaluation of Clinical, Microbiological and Cytomorphometric Parameters.

Stanković Ivana, Obradović Radmila, Pejčić Ana, Kitić Dušanka, Petrović Milica, Toljić Boško, Bradić-Vasić Marija, Živadinović Katarina

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Аннотация

Objectives

Periodontitis represents an inflammatory condition affecting the supporting structures of teeth. Basic therapy relies on scaling and root planning, but often fails to eliminate subgingival pathogens. Phytotherapy has emerged as an adjunct due to its antimicrobial, anti-inflammatory, antioxidant, and tissue-protective properties. The aim of this study was to evaluate the effects of the phytotherapeutic product Propoherb G® as an adjunct to mechanical periodontal therapy.

Methods

This study included 90 systemically healthy participants divided into three groups: control, basic therapy, and basic therapy + Propoherb G®. Periodontal clinical parameters were assessed, alongside the presence of periodontopathogens (A. actinomycetemcomitans, P. gingivalis, and T. denticola) using PCR and cytomorphometric analysis of gingival cells at baseline, first day, and eleven days after therapy.

Results

Results showed significant improvements in periodontal clinical parameters in both treatment groups, with the most pronounced effect observed in the Propoherb G® group (p < 0.001). A marked reduction in periodontopathogenic bacteria was achieved, with Propoherb G® demonstrating sustained elimination of P. gingivalis and T. denticola, and a significant reduction of A. actinomycetemcomitans compared to standard therapy alone (p < 0.001). The control group showed no significant changes. Cytomorphometric analysis showed a significant decrease in all measured cell parameters after therapy (p < 0.001) in the group with Propoherb G® preparation.

Conclusions

The adjunctive use of Propoherb G® enhances the clinical, microbiological and cytomorphometric outcomes of basic therapy. These findings support the potential of phytotherapy as a safe and effective supplement to basic treatment, although further studies with larger sample sizes and longer follow-up are necessary to standardize protocols and optimize clinical application.

Для цитирования: Stanković Ivana, Obradović Radmila, Pejčić Ana, Kitić Dušanka, Petrović Milica, Toljić Boško, Bradić-Vasić Marija, Živadinović Katarina. The Role of an Herbal Preparation in Enhancing the Efficacy of Basic Therapy in Patients with Periodontitis: Evaluation of Clinical, Microbiological and Cytomorphometric Parameters.. Pharmaceuticals (Basel, Switzerland). 2026. DOI: 10.3390/ph19040586.
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