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DOI 10.2217/bmm-2021-0076

Медицинская библиотека · Biomarkers in medicine · 2022

Folate metabolism abnormalities in infertile patients with endometriosis.

Guedes Tarciana, Santos Aline A, Vieira-Neto Felipe H, Bianco Bianca, Barbosa Caio P, Christofolini Denise M

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Background

Homocysteine levels can be impacted by enzymes variations. Aim: To correlate MTHFR, MTR and MTRR variants with homocysteine levels in the blood and follicular fluid and assisted reproduction results. Material & methods:MTHFR (rs2274976, rs1801131, rs1801133), MTR (rs1805087) and MTRR (rs1801394) genotyping was performed by TaqMan assays and compared with homocysteine levels, measured by ELISA, to oocytes retrieved and to the pregnancy status of women with endometriosis and controls.

Results

The MTR G allele and GG genotype were more common in patients with endometriosis. They also showed lower levels of homocysteine and more clinical gestations. Epistasis analysis showed a model associated with gestational results, composed of MTHFR+MTR variants (CC+AG).

Conclusion

The summation effect of variants in genes participating in folate metabolism was associated with pregnancy status in Brazilian women. MTR variants were more observed in endometriosis patients, as well as lower follicular Hcy levels and increased clinical pregnancy results.

Для цитирования: Guedes Tarciana, Santos Aline A, Vieira-Neto Felipe H, Bianco Bianca, Barbosa Caio P, Christofolini Denise M. Folate metabolism abnormalities in infertile patients with endometriosis.. Biomarkers in medicine. 2022. DOI: 10.2217/bmm-2021-0076.

Предметные рубрики MeSH

5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseAllelesEndometriosisFemaleFerredoxin-NADP ReductaseFolic AcidGenotypeHomocysteineHumansMethylenetetrahydrofolate Reductase (NADPH2)Polymorphism, Single NucleotidePregnancy
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