European journal of radiology · 2025
Choroid plexus volume and association with migraine Pathophysiology.
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Xiong Jianmei, Liu Mengqi, Li Xin, Chen Zhiye
Аннотация
BACKGROUND: Direct evidence of choroid plexus structures involved in the presumed peripheral-central interaction in migraine is exceptionally scarce and, thus, which demands further attention.
OBJECTIVES: Our objective is to assess choroid plexus volumetric changes quantitatively in episodic and chronic migraine patients versus age and sex compared normal controls, and to elucidate the differences.
METHODS: Total sixty-five participants including 18 episodic migraine patients, 16 chronic migraine patients and 31 normal controls were recruited and underwent brain MRI examinations with 3.0 T MR strength between September 2021 to May 2023. The choroid plexus of the ventricles was segmented automatically on T1-weighted MRI sequences using the FreeSurfer (Version 7.4.1) software. Lateral ventricular choroid plexus volume was normalized as the ratio of choroid plexus to ipsilateral lateral ventricle volume (CP/LV). Group differences were assessed cross-sectionally. The accuracy of CP/LV for prediction of migraine was assessed using the receiver operating characteristic curves analysis.
RESULTS: Patients with migraine were more anxious and depressive, with heavier headache burden and impaired cognitive ability. Statistical analysis revealed group differences of the CP/LV in the right side. CP/LV ration decreased in episodic migraine patients, but the CP/LV size increased in chronic migraine patients. CP/LV of the right side was able to differentiate episodic migraine from controls with area under the ROC curve (AUC) 0.696 (95 % CI: 0.550-0.818, sensitivity 100 %, specificity 46.8 %, and the cut-off value 0.0741, P < 0.05). The diagnostic efficacy was marginally higher in distinguishing chronic migraine from episodic migraine with AUC 0.715(95 % CI: 0.536-0.856, sensitivity 50 %, specificity 94.4 % and the cut-off value 0.0725, P < 0.05).
CONCLUSION: Our finding suggested dynamic alteration of Lateral ventricular choroid plexus volume in the pathogenesis of migraine. The normalized CP/LV was associated with different migraine subtype. The normalized CP/LV can be used as a potential imaging biomarker for migraine diagnosis.
OBJECTIVES: Our objective is to assess choroid plexus volumetric changes quantitatively in episodic and chronic migraine patients versus age and sex compared normal controls, and to elucidate the differences.
METHODS: Total sixty-five participants including 18 episodic migraine patients, 16 chronic migraine patients and 31 normal controls were recruited and underwent brain MRI examinations with 3.0 T MR strength between September 2021 to May 2023. The choroid plexus of the ventricles was segmented automatically on T1-weighted MRI sequences using the FreeSurfer (Version 7.4.1) software. Lateral ventricular choroid plexus volume was normalized as the ratio of choroid plexus to ipsilateral lateral ventricle volume (CP/LV). Group differences were assessed cross-sectionally. The accuracy of CP/LV for prediction of migraine was assessed using the receiver operating characteristic curves analysis.
RESULTS: Patients with migraine were more anxious and depressive, with heavier headache burden and impaired cognitive ability. Statistical analysis revealed group differences of the CP/LV in the right side. CP/LV ration decreased in episodic migraine patients, but the CP/LV size increased in chronic migraine patients. CP/LV of the right side was able to differentiate episodic migraine from controls with area under the ROC curve (AUC) 0.696 (95 % CI: 0.550-0.818, sensitivity 100 %, specificity 46.8 %, and the cut-off value 0.0741, P < 0.05). The diagnostic efficacy was marginally higher in distinguishing chronic migraine from episodic migraine with AUC 0.715(95 % CI: 0.536-0.856, sensitivity 50 %, specificity 94.4 % and the cut-off value 0.0725, P < 0.05).
CONCLUSION: Our finding suggested dynamic alteration of Lateral ventricular choroid plexus volume in the pathogenesis of migraine. The normalized CP/LV was associated with different migraine subtype. The normalized CP/LV can be used as a potential imaging biomarker for migraine diagnosis.