Медицинская библиотека · Science (New York, N.Y.) · 2022

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.

Tegally Houriiyah, San James E, Cotten Matthew, Moir Monika, Tegomoh Bryan, Mboowa Gerald, Martin Darren P, Baxter Cheryl, Lambisia Arnold W, Diallo Amadou, Amoako Daniel G, Diagne Moussa M, Sisay Abay, Zekri Abdel-Rahman N, Gueye Abdou Salam, Sangare Abdoul K, Ouedraogo Abdoul-Salam, Sow Abdourahmane, Musa Abdualmoniem O, Sesay Abdul K, Abias Abe G, Elzagheid Adam I, Lagare Adamou, Kemi Adedotun-Sulaiman, Abar Aden Elmi, Johnson Adeniji A, Fowotade Adeola, Oluwapelumi Adeyemi O, Amuri Adrienne A, Juru Agnes, Kandeil Ahmed, Mostafa Ahmed, Rebai Ahmed, Sayed Ahmed, Kazeem Akano, Balde Aladje, Christoffels Alan, Trotter Alexander J, Campbell Allan, Keita Alpha K, Kone Amadou, Bouzid Amal, Souissi Amal, Agweyu Ambrose, Naguib Amel, Gutierrez Ana V, Nkeshimana Anatole, Page Andrew J, Yadouleton Anges, Vinze Anika, Happi Anise N, Chouikha Anissa, Iranzadeh Arash, Maharaj Arisha, Batchi-Bouyou Armel L, Ismail Arshad, Sylverken Augustina A, Goba Augustine, Femi Ayoade, Sijuwola Ayotunde E, Marycelin Baba, Salako Babatunde L, Oderinde Bamidele S, Bolajoko Bankole, Diarra Bassirou, Herring Belinda L, Tsofa Benjamin, Lekana-Douki Bernard, Mvula Bernard, Njanpop-Lafourcade Berthe-Marie, Marondera Blessing T, Khaireh Bouh Abdi, Kouriba Bourema, Adu Bright, Pool Brigitte, McInnis Bronwyn, Brook Cara, Williamson Carolyn, Nduwimana Cassien, Anscombe Catherine, Pratt Catherine B, Scheepers Cathrine, Akoua-Koffi Chantal G, Agoti Charles N, Mapanguy Chastel M, Loucoubar Cheikh, Onwuamah Chika K, Ihekweazu Chikwe, Malaka Christian N, Peyrefitte Christophe, Grace Chukwa, Omoruyi Chukwuma E, Rafaï Clotaire D, Morang'a Collins M, Erameh Cyril, Lule Daniel B, Bridges Daniel J, Mukadi-Bamuleka Daniel, Park Danny, Rasmussen David A, Baker David, Nokes David J, Ssemwanga Deogratius, Tshiabuila Derek, Amuzu Dominic S Y, Goedhals Dominique, Grant Donald S, Omuoyo Donwilliams O, Maruapula Dorcas, Wanjohi Dorcas W, Foster-Nyarko Ebenezer, Lusamaki Eddy K, Simulundu Edgar, Ong'era Edidah M, Ngabana Edith N, Abworo Edward O, Otieno Edward, Shumba Edwin, Barasa Edwine, Ahmed El Bara, Ahmed Elhadi A, Lokilo Emmanuel, Mukantwari Enatha, Philomena Eromon, Belarbi Essia, Simon-Loriere Etienne, Anoh Etilé A, Manuel Eusebio, Leendertz Fabian, Taweh Fahn M, Wasfi Fares, Abdelmoula Fatma, Takawira Faustinos T, Derrar Fawzi, Ajogbasile Fehintola V, Treurnicht Florette, Onikepe Folarin, Ntoumi Francine, Muyembe Francisca M, Ragomzingba Frank E Z, Dratibi Fred A, Iyanu Fred-Akintunwa, Mbunsu Gabriel K, Thilliez Gaetan, Kay Gemma L, Akpede George O, van Zyl Gert U, Awandare Gordon A, Kpeli Grace S, Schubert Grit, Maphalala Gugu P, Ranaivoson Hafaliana C, Omunakwe Hannah E, Onywera Harris, Abe Haruka, Karray Hela, Nansumba Hellen, Triki Henda, Kadjo Herve Albéric Adje, Elgahzaly Hesham, Gumbo Hlanai, Mathieu Hota, Kavunga-Membo Hugo, Smeti Ibtihel, Olawoye Idowu B, Adetifa Ifedayo M O, Odia Ikponmwosa, Ben Boubaker Ilhem Boutiba, Muhammad Iluoreh Ahmed, Ssewanyana Isaac, Wurie Isatta, Konstantinus Iyaloo S, Halatoko Jacqueline Wemboo Afiwa, Ayei James, Sonoo Janaki, Makangara Jean-Claude C, Tamfum Jean-Jacques M, Heraud Jean-Michel, Shaffer Jeffrey G, Giandhari Jennifer, Musyoki Jennifer, Nkurunziza Jerome, Uwanibe Jessica N, Bhiman Jinal N, Yasuda Jiro, Morais Joana, Kiconco Jocelyn, Sandi John D, Huddleston John, Odoom John K, Morobe John M, Gyapong John O, Kayiwa John T, Okolie Johnson C, Xavier Joicymara S, Gyamfi Jones, Wamala Joseph F, Bonney Joseph H K, Nyandwi Joseph, Everatt Josie, Nakaseegu Joweria, Ngoi Joyce M, Namulondo Joyce, Oguzie Judith U, Andeko Julia C, Lutwama Julius J, Mogga Juma J H, O'Grady Justin, Siddle Katherine J, Victoir Kathleen, Adeyemi Kayode T, Tumedi Kefentse A, Carvalho Kevin S, Mohammed Khadija Said, Dellagi Koussay, Musonda Kunda G, Duedu Kwabena O, Fki-Berrajah Lamia, Singh Lavanya, Kepler Lenora M, Biscornet Leon, de Oliveira Martins Leonardo, Chabuka Lucious, Olubayo Luicer, Ojok Lul Deng, Deng Lul Lojok, Ochola-Oyier Lynette I, Tyers Lynn, Mine Madisa, Ramuth Magalutcheemee, Mastouri Maha, ElHefnawi Mahmoud, Mbanne Maimouna, Matsheka Maitshwarelo I, Kebabonye Malebogo, Diop Mamadou, Momoh Mambu, Lima Mendonça Maria da Luz, Venter Marietjie, Paye Marietou F, Faye Martin, Nyaga Martin M, Mareka Mathabo, Damaris Matoke-Muhia, Mburu Maureen W, Mpina Maximillian G, Owusu Michael, Wiley Michael R, Tatfeng Mirabeau Y, Ayekaba Mitoha Ondo'o, Abouelhoda Mohamed, Beloufa Mohamed Amine, Seadawy Mohamed G, Khalifa Mohamed K, Matobo Mooko Marethabile, Kane Mouhamed, Salou Mounerou, Mbulawa Mphaphi B, Mwenda Mulenga, Allam Mushal, Phan My V T, Abid Nabil, Rujeni Nadine, Abuzaid Nadir, Ismael Nalia, Elguindy Nancy, Top Ndeye Marieme, Dia Ndongo, Mabunda Nédio, Hsiao Nei-Yuan, Silochi Nelson Boricó, Francisco Ngiambudulu M, Saasa Ngonda, Bbosa Nicholas, Murunga Nickson, Gumede Nicksy, Wolter Nicole, Sitharam Nikita, Ndodo Nnaemeka, Ajayi Nnennaya A, Tordo Noël, Mbhele Nokuzola, Razanajatovo Norosoa H, Iguosadolo Nosamiefan, Mba Nwando, Kingsley Ojide C, Sylvanus Okogbenin, Femi Oladiji, Adewumi Olubusuyi M, Testimony Olumade, Ogunsanya Olusola A, Fakayode Oluwatosin, Ogah Onwe E, Oludayo Ope-Ewe, Faye Ousmane, Smith-Lawrence Pamela, Ondoa Pascale, Combe Patrice, Nabisubi Patricia, Semanda Patrick, Oluniyi Paul E, Arnaldo Paulo, Quashie Peter Kojo, Okokhere Peter O, Bejon Philip, Dussart Philippe, Bester Phillip A, Mbala Placide K, Kaleebu Pontiano, Abechi Priscilla, El-Shesheny Rabeh, Joseph Rageema, Aziz Ramy Karam, Essomba René G, Ayivor-Djanie Reuben, Njouom Richard, Phillips Richard O, Gorman Richmond, Kingsley Robert A, Neto Rodrigues Rosa Maria D E S A, Audu Rosemary A, Carr Rosina A A, Gargouri Saba, Masmoudi Saber, Bootsma Sacha, Sankhe Safietou, Mohamed Sahra Isse, Femi Saibu, Mhalla Salma, Hosch Salome, Kassim Samar Kamal, Metha Samar, Trabelsi Sameh, Agwa Sara Hassan, Mwangi Sarah Wambui, Doumbia Seydou, Makiala-Mandanda Sheila, Aryeetey Sherihane, Ahmed Shymaa S, Ahmed Side Mohamed, Elhamoumi Siham, Moyo Sikhulile, Lutucuta Silvia, Gaseitsiwe Simani, Jalloh Simbirie, Andriamandimby Soa Fy, Oguntope Sobajo, Grayo Solène, Lekana-Douki Sonia, Prosolek Sophie, Ouangraoua Soumeya, van Wyk Stephanie, Schaffner Stephen F, Kanyerezi Stephen, Ahuka-Mundeke Steve, Rudder Steven, Pillay Sureshnee, Nabadda Susan, Behillil Sylvie, Budiaki Sylvie L, van der Werf Sylvie, Mashe Tapfumanei, Mohale Thabo, Le-Viet Thanh, Velavan Thirumalaisamy P, Schindler Tobias, Maponga Tongai G, Bedford Trevor, Anyaneji Ugochukwu J, Chinedu Ugwu, Ramphal Upasana, George Uwem E, Enouf Vincent, Nene Vishvanath, Gorova Vivianne, Roshdy Wael H, Karim Wasim Abdul, Ampofo William K, Preiser Wolfgang, Choga Wonderful T, Ahmed Yahaya Ali, Ramphal Yajna, Bediako Yaw, Naidoo Yeshnee, Butera Yvan, de Laurent Zaydah R, Africa Pathogen Genomics Initiative (Africa PGI)‡, Ouma Ahmed E O, von Gottberg Anne, Githinji George, Moeti Matshidiso, Tomori Oyewale, Sabeti Pardis C, Sall Amadou A, Oyola Samuel O, Tebeje Yenew K, Tessema Sofonias K, de Oliveira Tulio, Happi Christian, Lessells Richard, Nkengasong John, Wilkinson Eduan

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Аннотация

Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the pandemic on the continent, a number that now exceeds 100,000 genomes. Our results show an increase in the number of African countries that are able to sequence domestically and highlight that local sequencing enables faster turnaround times and more-regular routine surveillance. Despite limitations of low testing proportions, findings from this genomic surveillance study underscore the heterogeneous nature of the pandemic and illuminate the distinct dispersal dynamics of variants of concern-particularly Alpha, Beta, Delta, and Omicron-on the continent. Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve while the continent faces many emerging and reemerging infectious disease threats. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century.

Для цитирования: Tegally Houriiyah, San James E, Cotten Matthew, Moir Monika, Tegomoh Bryan, Mboowa Gerald, Martin Darren P, Baxter Cheryl, Lambisia Arnold W, Diallo Amadou, Amoako Daniel G, Diagne Moussa M, Sisay Abay, Zekri Abdel-Rahman N, Gueye Abdou Salam, Sangare Abdoul K, Ouedraogo Abdoul-Salam, Sow Abdourahmane, Musa Abdualmoniem O, Sesay Abdul K, Abias Abe G, Elzagheid Adam I, Lagare Adamou, Kemi Adedotun-Sulaiman, Abar Aden Elmi, Johnson Adeniji A, Fowotade Adeola, Oluwapelumi Adeyemi O, Amuri Adrienne A, Juru Agnes, Kandeil Ahmed, Mostafa Ahmed, Rebai Ahmed, Sayed Ahmed, Kazeem Akano, Balde Aladje, Christoffels Alan, Trotter Alexander J, Campbell Allan, Keita Alpha K, Kone Amadou, Bouzid Amal, Souissi Amal, Agweyu Ambrose, Naguib Amel, Gutierrez Ana V, Nkeshimana Anatole, Page Andrew J, Yadouleton Anges, Vinze Anika, Happi Anise N, Chouikha Anissa, Iranzadeh Arash, Maharaj Arisha, Batchi-Bouyou Armel L, Ismail Arshad, Sylverken Augustina A, Goba Augustine, Femi Ayoade, Sijuwola Ayotunde E, Marycelin Baba, Salako Babatunde L, Oderinde Bamidele S, Bolajoko Bankole, Diarra Bassirou, Herring Belinda L, Tsofa Benjamin, Lekana-Douki Bernard, Mvula Bernard, Njanpop-Lafourcade Berthe-Marie, Marondera Blessing T, Khaireh Bouh Abdi, Kouriba Bourema, Adu Bright, Pool Brigitte, McInnis Bronwyn, Brook Cara, Williamson Carolyn, Nduwimana Cassien, Anscombe Catherine, Pratt Catherine B, Scheepers Cathrine, Akoua-Koffi Chantal G, Agoti Charles N, Mapanguy Chastel M, Loucoubar Cheikh, Onwuamah Chika K, Ihekweazu Chikwe, Malaka Christian N, Peyrefitte Christophe, Grace Chukwa, Omoruyi Chukwuma E, Rafaï Clotaire D, Morang'a Collins M, Erameh Cyril, Lule Daniel B, Bridges Daniel J, Mukadi-Bamuleka Daniel, Park Danny, Rasmussen David A, Baker David, Nokes David J, Ssemwanga Deogratius, Tshiabuila Derek, Amuzu Dominic S Y, Goedhals Dominique, Grant Donald S, Omuoyo Donwilliams O, Maruapula Dorcas, Wanjohi Dorcas W, Foster-Nyarko Ebenezer, Lusamaki Eddy K, Simulundu Edgar, Ong'era Edidah M, Ngabana Edith N, Abworo Edward O, Otieno Edward, Shumba Edwin, Barasa Edwine, Ahmed El Bara, Ahmed Elhadi A, Lokilo Emmanuel, Mukantwari Enatha, Philomena Eromon, Belarbi Essia, Simon-Loriere Etienne, Anoh Etilé A, Manuel Eusebio, Leendertz Fabian, Taweh Fahn M, Wasfi Fares, Abdelmoula Fatma, Takawira Faustinos T, Derrar Fawzi, Ajogbasile Fehintola V, Treurnicht Florette, Onikepe Folarin, Ntoumi Francine, Muyembe Francisca M, Ragomzingba Frank E Z, Dratibi Fred A, Iyanu Fred-Akintunwa, Mbunsu Gabriel K, Thilliez Gaetan, Kay Gemma L, Akpede George O, van Zyl Gert U, Awandare Gordon A, Kpeli Grace S, Schubert Grit, Maphalala Gugu P, Ranaivoson Hafaliana C, Omunakwe Hannah E, Onywera Harris, Abe Haruka, Karray Hela, Nansumba Hellen, Triki Henda, Kadjo Herve Albéric Adje, Elgahzaly Hesham, Gumbo Hlanai, Mathieu Hota, Kavunga-Membo Hugo, Smeti Ibtihel, Olawoye Idowu B, Adetifa Ifedayo M O, Odia Ikponmwosa, Ben Boubaker Ilhem Boutiba, Muhammad Iluoreh Ahmed, Ssewanyana Isaac, Wurie Isatta, Konstantinus Iyaloo S, Halatoko Jacqueline Wemboo Afiwa, Ayei James, Sonoo Janaki, Makangara Jean-Claude C, Tamfum Jean-Jacques M, Heraud Jean-Michel, Shaffer Jeffrey G, Giandhari Jennifer, Musyoki Jennifer, Nkurunziza Jerome, Uwanibe Jessica N, Bhiman Jinal N, Yasuda Jiro, Morais Joana, Kiconco Jocelyn, Sandi John D, Huddleston John, Odoom John K, Morobe John M, Gyapong John O, Kayiwa John T, Okolie Johnson C, Xavier Joicymara S, Gyamfi Jones, Wamala Joseph F, Bonney Joseph H K, Nyandwi Joseph, Everatt Josie, Nakaseegu Joweria, Ngoi Joyce M, Namulondo Joyce, Oguzie Judith U, Andeko Julia C, Lutwama Julius J, Mogga Juma J H, O'Grady Justin, Siddle Katherine J, Victoir Kathleen, Adeyemi Kayode T, Tumedi Kefentse A, Carvalho Kevin S, Mohammed Khadija Said, Dellagi Koussay, Musonda Kunda G, Duedu Kwabena O, Fki-Berrajah Lamia, Singh Lavanya, Kepler Lenora M, Biscornet Leon, de Oliveira Martins Leonardo, Chabuka Lucious, Olubayo Luicer, Ojok Lul Deng, Deng Lul Lojok, Ochola-Oyier Lynette I, Tyers Lynn, Mine Madisa, Ramuth Magalutcheemee, Mastouri Maha, ElHefnawi Mahmoud, Mbanne Maimouna, Matsheka Maitshwarelo I, Kebabonye Malebogo, Diop Mamadou, Momoh Mambu, Lima Mendonça Maria da Luz, Venter Marietjie, Paye Marietou F, Faye Martin, Nyaga Martin M, Mareka Mathabo, Damaris Matoke-Muhia, Mburu Maureen W, Mpina Maximillian G, Owusu Michael, Wiley Michael R, Tatfeng Mirabeau Y, Ayekaba Mitoha Ondo'o, Abouelhoda Mohamed, Beloufa Mohamed Amine, Seadawy Mohamed G, Khalifa Mohamed K, Matobo Mooko Marethabile, Kane Mouhamed, Salou Mounerou, Mbulawa Mphaphi B, Mwenda Mulenga, Allam Mushal, Phan My V T, Abid Nabil, Rujeni Nadine, Abuzaid Nadir, Ismael Nalia, Elguindy Nancy, Top Ndeye Marieme, Dia Ndongo, Mabunda Nédio, Hsiao Nei-Yuan, Silochi Nelson Boricó, Francisco Ngiambudulu M, Saasa Ngonda, Bbosa Nicholas, Murunga Nickson, Gumede Nicksy, Wolter Nicole, Sitharam Nikita, Ndodo Nnaemeka, Ajayi Nnennaya A, Tordo Noël, Mbhele Nokuzola, Razanajatovo Norosoa H, Iguosadolo Nosamiefan, Mba Nwando, Kingsley Ojide C, Sylvanus Okogbenin, Femi Oladiji, Adewumi Olubusuyi M, Testimony Olumade, Ogunsanya Olusola A, Fakayode Oluwatosin, Ogah Onwe E, Oludayo Ope-Ewe, Faye Ousmane, Smith-Lawrence Pamela, Ondoa Pascale, Combe Patrice, Nabisubi Patricia, Semanda Patrick, Oluniyi Paul E, Arnaldo Paulo, Quashie Peter Kojo, Okokhere Peter O, Bejon Philip, Dussart Philippe, Bester Phillip A, Mbala Placide K, Kaleebu Pontiano, Abechi Priscilla, El-Shesheny Rabeh, Joseph Rageema, Aziz Ramy Karam, Essomba René G, Ayivor-Djanie Reuben, Njouom Richard, Phillips Richard O, Gorman Richmond, Kingsley Robert A, Neto Rodrigues Rosa Maria D E S A, Audu Rosemary A, Carr Rosina A A, Gargouri Saba, Masmoudi Saber, Bootsma Sacha, Sankhe Safietou, Mohamed Sahra Isse, Femi Saibu, Mhalla Salma, Hosch Salome, Kassim Samar Kamal, Metha Samar, Trabelsi Sameh, Agwa Sara Hassan, Mwangi Sarah Wambui, Doumbia Seydou, Makiala-Mandanda Sheila, Aryeetey Sherihane, Ahmed Shymaa S, Ahmed Side Mohamed, Elhamoumi Siham, Moyo Sikhulile, Lutucuta Silvia, Gaseitsiwe Simani, Jalloh Simbirie, Andriamandimby Soa Fy, Oguntope Sobajo, Grayo Solène, Lekana-Douki Sonia, Prosolek Sophie, Ouangraoua Soumeya, van Wyk Stephanie, Schaffner Stephen F, Kanyerezi Stephen, Ahuka-Mundeke Steve, Rudder Steven, Pillay Sureshnee, Nabadda Susan, Behillil Sylvie, Budiaki Sylvie L, van der Werf Sylvie, Mashe Tapfumanei, Mohale Thabo, Le-Viet Thanh, Velavan Thirumalaisamy P, Schindler Tobias, Maponga Tongai G, Bedford Trevor, Anyaneji Ugochukwu J, Chinedu Ugwu, Ramphal Upasana, George Uwem E, Enouf Vincent, Nene Vishvanath, Gorova Vivianne, Roshdy Wael H, Karim Wasim Abdul, Ampofo William K, Preiser Wolfgang, Choga Wonderful T, Ahmed Yahaya Ali, Ramphal Yajna, Bediako Yaw, Naidoo Yeshnee, Butera Yvan, de Laurent Zaydah R, Africa Pathogen Genomics Initiative (Africa PGI)‡, Ouma Ahmed E O, von Gottberg Anne, Githinji George, Moeti Matshidiso, Tomori Oyewale, Sabeti Pardis C, Sall Amadou A, Oyola Samuel O, Tebeje Yenew K, Tessema Sofonias K, de Oliveira Tulio, Happi Christian, Lessells Richard, Nkengasong John, Wilkinson Eduan. The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.. Science (New York, N.Y.). 2022. DOI: 10.1126/science.abq5358.

Предметные рубрики MeSH

Africa COVID-19 Epidemiological Monitoring Genomics Humans Pandemics SARS-CoV-2

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