Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2026
Calcium Signaling Modulator 4-MPTC Reduces Proliferative and Migration Activities of MDA-MB-468 Breast Cancer Cells.
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Skopin A Yu, Gusev K O, Grekhnev D A, Glushankova L N, Kartsev V G, Kaznacheyeva E V
Аннотация
Cell malignant transformation is accompanied by a remodeling of various cell life-support systems, including calcium signaling. Modulation of the calcium signal can significantly sensitize cancer cells, making them more sensitive to anticancer drugs. A search for selective compounds that influence the cell calcium response is a promising area in the development of combination therapies for oncology diseases. The aim of this study was to determine the effect of 4-MPTC on the invasive potential of triple-negative breast cancer cells. 4-MPTC was previously selected as a modulator of the Stim2-dependent calcium entry pathway via a small molecule screening. 4-MPTC was shown to induce a massive calcium release from the intracellular calcium store in the endoplasmic reticulum (ER), blocks store-operated calcium entry, and reduces proliferation and migration activity of MDA-MB-468 triple-negative breast cancer cells.