Nature communications · 2024
Genomic insights into the 2022-2023Vibrio cholerae outbreak in Malawi.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Chaguza Chrispin, Chibwe Innocent, Chaima David, Musicha Patrick, Ndeketa Latif, Kasambara Watipaso, Mhango Chimwemwe, Mseka Upendo L, Bitilinyu-Bangoh Joseph, Mvula Bernard, Kipandula Wakisa, Bonongwe Patrick, Munthali Richard J, Ngwira Selemani, Mwendera Chikondi A, Kalizang'oma Akuzike, Jambo Kondwani C, Kambalame Dzinkambani, Kamng'ona Arox W, Steele A Duncan, Chauma-Mwale Annie, Hungerford Daniel, Kagoli Matthew, Nyaga Martin M, Dube Queen, French Neil, Msefula Chisomo L, Cunliffe Nigel A, Jere Khuzwayo C
Аннотация
Malawi experienced its deadliest Vibrio cholerae (Vc) outbreak following devastating cyclones, with >58,000 cases and >1700 deaths reported between March 2022 and May 2023. Here, we use population genomics to investigate the attributes and origin of the Malawi 2022-2023 Vc outbreak isolates. Our results demonstrate the predominance of ST69 clone, also known as the seventh cholera pandemic El Tor (7PET) lineage, expressing O1 Ogawa (~ 80%) serotype followed by Inaba (~ 16%) and sporadic non-O1/non-7PET serogroups (~ 4%). Phylogenetic reconstruction revealed that the Malawi outbreak strains correspond to a recent importation from Asia into Africa (sublineage AFR15). These isolates harboured known antimicrobial resistance and virulence elements, notably the ICEGEN/ICEVchHai1/ICEVchind5 SXT/R391-like integrative conjugative elements and a CTXφ prophage with the ctxB7 genotype compared to historical Malawian Vc isolates. These data suggest that the devastating cyclones coupled with the recent importation of 7PET serogroup O1 strains, may explain the magnitude of the 2022-2023 cholera outbreak in Malawi.