[Pregnancy outcome of frozen-thawed embryo transfers in different endometrial progesterone preparation time].

OBJECTIVE

To investigate the pregnancy outcome of frozen-thawed embryos transfer in different endometrial progesterone preparation time.

METHODS

From January to December 2012, pregnant outcome of 1 103 frozen-thawed embryo transfer cycles using artificial periodic endometrial preparation were studied retrospectively in Reproductive Medical Center of Henan Provincial People's Hospital. It was divided into 4 groups: group 3-3 (n = 543, 3 days after endometrial progesterone preparation and transfer D3 embryo), group 4-3(n = 330, 4 days after endometrial progesterone preparation and transfer D3 embryo), group 5-5 (n = 150, 5 days after endometrial progesterone preparation and transfer D5 blastula), group 6-5 (n = 80, 6 days after endometrial progesterone preparation and transfer D5 blastula). The rate of implantation, pregnancy, ectopic pregnancy, multiple pregnancy, and first trimester abortion were compared among those groups.

RESULTS

(1) With the different endometrial progesterone preparation methods and transfer D3 embryos, implantation rate [group 3-3:39.9% (429/1 074); group 4-3:44.1% (286/648)], pregnancy rate [group 3-3:56.0% (304/543); group 4-3:59.4% (196/330)], ectopic pregnancy rate [group 3-3:3.3% (10/304); group 4-3:2.6% (5/196)], multiple pregnancy rate[group 3-3: 38.5% (117/304) ; group 4-3: 43.4% (85/196)]and early abortion rate [group 3-3: 13.5% (41/304); group 4-3:13.3% (26/196)] had no significant differences between group 3-3 and group 4-3 (all P > 0.05). (2) With the different endometrial progesterone preparation methods and transfer D5 blastocysts, implantation rate [group 5-5:64.7% (191/295) ; group 6-5:69.4% (100/144)], pregnancy rate [group 5-5:80.7% (121/150) ; group 6-5:78.8% (63/80)], ectopic pregnancy rate [group 5-5:2.5% (3/121); group 6-5:0], multiple pregnancy rate[group 5-5:55.4% (67/121); group 6-5: 46.3% (37/80)] and early abortion rate [group 5-5: 5.8% (7/121); group 6-5:7.9% (5/63)]. However, there were no significantly differences between group 5-5 and group 6-5(all P > 0.05).

CONCLUSIONS

The two different progesterone transformed endometrial methods can obtain satisfactory clinical outcome with D3 embryo or D5 blastocysts transfor. It is convenient to clinical and laboratory work arrangements.