Effect of oxygen on the respiratory system and cephalosporin-C production in Acremonium chrysogenum.

In this paper in vivo studies on the overall and cyanide-resistant respiration of Acremonium chrysogenum in connection with different oxygen transfer rates are discussed. Two parameters of the cyanide-resistant respiration, the activity and the capacity were examined separately during cultivation together with the possibly respiration-influencing factors like NADH/NAD content and ADP-limitation. It was finally concluded that the cyanide-resistant respiration seems to be independent of the amount and proportion of oxidized/reduced coenzymes and not limited by ADP or phosphate, but it is strongly affected by the oxygen available. It was also established that the examined path must have an important role in cephalosporin-C overproduction.