Journal of cardiovascular pharmacology · 1986
Comparative effects of propranolol and pindolol on small and large arteries and veins of the forearm circulation in hypertensive man.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Maarek B L, Bouthier J A, Simon A C, Levenson J A, Safar M E
Аннотация
Brachial artery diameter (pulsed Doppler method), forearm vascular resistance, and venous tone (plethysmographic method) were studied in 18 patients with sustained essential hypertension. Hemodynamic parameters were reevaluated after 3 months of treatment by propranolol (9 patients) or pindolol (9 patients). For the same decrease in pressure, propranolol decreased heart rate significantly while pindolol did not, indicating the role of intrinsic sympathomimetic activity. After pindolol, forearm vascular resistance and venous tone significantly decreased while brachial artery cross-sectional area significantly increased. After propranolol, forearm vascular resistance and brachial artery cross-sectional area did not change significantly, while forearm venous tone increased markedly. The study shows that, in the long term, pindolol dilates small and large arteries and veins of the forearm circulation whereas Propranolol apparently does not.