Fetal diagnosis and therapy · 2006
Parvovirus B19 infection in pregnancy studied by maternal viral load and immune responses.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
de Haan Timo R, Beersma Matthias F C, Claas Eric C J, Oepkes Dick, Kroes Aloys C M, Walther Frans J
Аннотация
OBJECTIVES: Facilitate risk assessment of vital complications in fetuses of pregnancies affected by acute parvovirus B19 (B19V) infection.
DESIGN: Study of the natural course of maternal B19V infection in four cases, from early pregnancy on.
SETTING: University Medical Center in the Netherlands.
POPULATION: Pregnant mothers attending obstetric services.
METHODS: Serial measurements of the maternal and fetal or neonatal viral load and antibody responses.
MAIN OUTCOME MEASURES: Maternal and fetal/neonatal serum B19V viral DNA load and specific IgM and IgG antibodies in maternal serum.
RESULTS: Peak viral load levels occurred within 1 week after maternal infection and peak IgM levels were observed 1 week after the peak viral load levels. Approximation of IgG and IgM ratios usually took place 4 weeks after infection. Vertical transmission occurred 1-3 weeks after maternal infection, suggesting that fetal infection occurs during the maternal peak viral load.
CONCLUSIONS: Maternal B19V DNA load levels and IgM responses are useful to estimate the risk of parvovirus B19-associated fetal complications. The maternal peak viral load directly precedes the onset of fetal infection and may be used to indicate the stage of intrauterine B19V infection.
DESIGN: Study of the natural course of maternal B19V infection in four cases, from early pregnancy on.
SETTING: University Medical Center in the Netherlands.
POPULATION: Pregnant mothers attending obstetric services.
METHODS: Serial measurements of the maternal and fetal or neonatal viral load and antibody responses.
MAIN OUTCOME MEASURES: Maternal and fetal/neonatal serum B19V viral DNA load and specific IgM and IgG antibodies in maternal serum.
RESULTS: Peak viral load levels occurred within 1 week after maternal infection and peak IgM levels were observed 1 week after the peak viral load levels. Approximation of IgG and IgM ratios usually took place 4 weeks after infection. Vertical transmission occurred 1-3 weeks after maternal infection, suggesting that fetal infection occurs during the maternal peak viral load.
CONCLUSIONS: Maternal B19V DNA load levels and IgM responses are useful to estimate the risk of parvovirus B19-associated fetal complications. The maternal peak viral load directly precedes the onset of fetal infection and may be used to indicate the stage of intrauterine B19V infection.