[Significance of neurospecific enolase determination in estimation of severity of hypoxic-ischemic injury of newborn brain].

The purpose of our research was the study of diagnostic possibility of neurospecific enolase (NSE) as a marker of hematoencephalic barrier (HEB) dysfunction in newborn infants of different gestational age with perinatal injury of central nervous system (CNS). It was determined that the concentration of NSE in blood serum by the immunoenzyme method in 98 newborns of different gestation age with hypoxic-ischemic injury of CNS in dynamics of neonatal period (0-1, 5-7, 12-14, 20-21, 28-30 days). It was found that the concentration of NSE was changed depending on the character of CNS injury (intraventricular hemorrhage, periventricular leucomalacia). This change had wavy character with maximum concentration at the 1st and 3rd weeks of life.