BMC neuroscience · 2004
Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Breuer Sebastian, Pech Katrin, Buss Armin, Spitzer Christoph, Ozols Juris, Hol Elly M, Heussen Nicole, Noth Johannes, Schwaiger Franz-Werner, Schmitt Andreas B
Аннотация
BACKGROUND: Interruption of mature axons activates a cascade of events in neuronal cell bodies which leads to various outcomes from functional regeneration in the PNS to the failure of any significant regeneration in the CNS. One factor which seems to play an important role in the molecular programs after axotomy is the stearoyl Coenzyme A-desaturase-1 (SCD-1). This enzyme is needed for the conversion of stearate into oleate. Beside its role in membrane synthesis, oleate could act as a neurotrophic factor, involved in signal transduction pathways via activation of protein kinases C.
RESULTS: In situ hybridization and immunohistochemistry demonstrated a strong up-regulation of SCD at mRNA and protein level in regenerating neurons of the rat facial nucleus whereas non-regenerating Clarke's and Red nucleus neurons did not show an induction of this gene.
CONCLUSION: This differential expression points to a functionally significant role for the SCD-1 in the process of regeneration.
RESULTS: In situ hybridization and immunohistochemistry demonstrated a strong up-regulation of SCD at mRNA and protein level in regenerating neurons of the rat facial nucleus whereas non-regenerating Clarke's and Red nucleus neurons did not show an induction of this gene.
CONCLUSION: This differential expression points to a functionally significant role for the SCD-1 in the process of regeneration.
Предметные рубрики MeSH
AnimalsAxotomyCentral Nervous SystemDisease ProgressionFacial Nerve InjuriesHypoglossal NerveHypoglossal Nerve InjuriesImmunohistochemistryIn Situ HybridizationIsoenzymesNerve RegenerationNeuronsPeripheral Nervous SystemPonsRNA, MessengerRatsRats, Sprague-DawleyRed NucleusSpinal Cord InjuriesStearoyl-CoA DesaturaseTrauma, Nervous SystemUp-Regulation