[Lipid peroxidation in women with gestational hypertension complicated by asymetric intrauterine growth retardation].

OBJECTIVES

Hypertension in pregnancy is connected with increased rate of prematurity and perinatal morbility. 8-isoprostane and lipid peroxides are the oxidative stress indices, similar to the prostaglandins both connected with vessels restriction.

DESIGN

The aim of the study was to find the correlation between concentration of lipid peroxides and 8-isoprostane and the blood pressure in pregnancy.

MATERIALS AND

METHODS

The study was done in Dep. of Obstetrics and Gynaecology Medical University in Lodz in 2002-2005. The study group consisted of 78 women with diagnosed hypertension in pregnancy, the control group of 50 healthy pregnant women at the same gestational age. Lipid peroxides and 8-isoprostane were measured in maternal blood. The Oxis Immunoassay for 8-epi prostaglandin and LPO 586 were used. The results were expressed in ng/ml and microM.

RESULTS

The concentration of 8-isoprostane in women with hypertension was 0,0691 ng/ml, in women with hypertension and IUGR the value of 8-isoprostane was similar--0,0728 ng/ml. In women in normal pregnancy was lower--0,0541 ng/ml. Lipid peroxides and 8-isoprostane concentration in both hypertensive groups was higher than in group of normotensive pregnant women.

CONCLUSIONS

In pregnancies complicated by hypertension the concentration of vasorestrictive lipid peroxidation products is higher than in normotensive women and the antioxidative treatment may be used to decrease lipid peroxidation process.