Fertility and sterility · 2008
Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tsai Hsiu-Ting, Wang Po-Hui, Tee Yi-Torng, Lin Long-Yau, Hsieh Yih-Shou, Yang Shun-Fa
Аннотация
OBJECTIVE: To detect the serum expression of cathepsin B and cystatin C and the ratio of cathepsin B to cystatin C in patients with pelvic inflammatory disease (PID) and speculate whether those are helpful indicators for the diagnosis of PID.
DESIGN: A random consecutive study.
SETTING: University hospital.
PATIENT(S): Forty-four women who were diagnosed with PID.
INTERVENTION(S): Collected blood specimens of patients before and after they received treatment.
MAIN OUTCOME MEASURE(S): ELISA analysis was used to measure the serum levels of cathepsin B and cystatin C.
RESULT(S): A significantly increased expression of cathepsin B but decreased expression of cystatin C and significant correlations between neutrophils and cathepsin B, as well as between C-reactive protein (CRP) and cathepsin B, were found in patients with PID. Consistently, the ratio of cathepsin B to cystatin C correlated significantly with neutrophils and with CRP in patients with PID.
CONCLUSION(S): Increased expression of cathepsin B but a decreased level of cystatin C and an imbalance between cathepsin B and cystatin C may contribute to the progression of PID. Detection of cathepsin B and cystatin C can provide useful clinical information for PID.
DESIGN: A random consecutive study.
SETTING: University hospital.
PATIENT(S): Forty-four women who were diagnosed with PID.
INTERVENTION(S): Collected blood specimens of patients before and after they received treatment.
MAIN OUTCOME MEASURE(S): ELISA analysis was used to measure the serum levels of cathepsin B and cystatin C.
RESULT(S): A significantly increased expression of cathepsin B but decreased expression of cystatin C and significant correlations between neutrophils and cathepsin B, as well as between C-reactive protein (CRP) and cathepsin B, were found in patients with PID. Consistently, the ratio of cathepsin B to cystatin C correlated significantly with neutrophils and with CRP in patients with PID.
CONCLUSION(S): Increased expression of cathepsin B but a decreased level of cystatin C and an imbalance between cathepsin B and cystatin C may contribute to the progression of PID. Detection of cathepsin B and cystatin C can provide useful clinical information for PID.