[Adenyl cyclase activity in the tissues and excretion of cyclic adenosine monophosphate in experimental arteriosclerosis].

The activity of adenylcyclase in the tissues and the elimination of 3',5'-AMP with urine were studied in rabbits and rats with experimentally induced atherosclerosis. The relationship between the concentration of steroid hormones and the activity of adenylcyclase in the adrenals was studied after varying periods of atherogenic diets. The activity of adenylcyclase was shown to decrease in the liver and the adrenal glands, as well as the concentration of corticosterone in the adrenals and the urine excretion of 3',5'-AMP, when the animals were kept on the atherogenic diet for long periods of time. No changes in the activity of adenylcyclase were noted in the lipid tissues of the animals with atherosclerosis. The concentration of the steroid hormones in the animals with experimental atherosclerosis was directly dependent on the activity of adenylcyclase in the tissues and the urine excretion of 3',5'-AMP. The administration of Cortisole resulted in a sharp increase of 3',5'-AMP excretion and an activation of adenylcyclase in the liver and lipid tissues of both normal animals, and those kept on an atherogenic diet.