Tremor and other hyperkinetic movements (New York, N.Y.) · 2018
Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Manzke Pedro, Grippe Talyta, Tavares Georgia L, Leal Lucas C, Roze Emmanuel, Apartis Emmanuelle, Maciel Dias Ronaldo, Ferreira André G F
Аннотация
BACKGROUND: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms.
CASE REPORT: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD.
DISCUSSION: Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglobulin, steroids, and other immunosuppressant agents.
CASE REPORT: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD.
DISCUSSION: Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglobulin, steroids, and other immunosuppressant agents.