The Australian & New Zealand journal of obstetrics & gynaecology · 2006
After the FLUSH trial: a prospective observational study of lipiodol flushing as an innovative treatment for unexplained and endometriosis-related infertility.
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Brent Kira, Hadden Wendy E, Weston-Webb Marianne, Johnson Neil P
Аннотация
OBJECTIVES: To assess the demographics, efficacy and safety of lipiodol flushing fertility treatment.
DESIGN: Prospective observational study.
SETTING: Secondary level care infertility clinic and radiology centre based in Auckland, New Zealand.
POPULATION: The first cohort of 100 New Zealand women with infertility to undergo lipiodol flushing as an innovative fertility treatment.
METHODS: Women received lipiodol flushing performed by a hysterosalpingogram technique and were followed up at 6 months.
MAIN OUTCOME MEASURES: Clinical pregnancy at 6 months post-treatment; and live birth or ongoing pregnancy.
RESULTS: The overall pregnancy rate was 30% and the live birth or ongoing pregnancy rate 27%. For women under 40 years old, a 32% pregnancy rate and a 25% live birth or ongoing pregnancy rate were seen in women with unexplained infertility, and a 50% pregnancy rate and a 47% live birth or ongoing pregnancy rate were seen in women with endometriosis. Of women aged 40 years and older, the pregnancy rate was 13% and the live birth or ongoing pregnancy rate was 13%. The pregnancy rates included those occurring after additional interventions, such as intrauterine insemination and in vitro fertilisation, accounting for 12 of the 30 pregnancies. There were no treatment complications.
CONCLUSION: This study provides further evidence of the efficacy and safety of lipiodol flushing fertility treatment.
DESIGN: Prospective observational study.
SETTING: Secondary level care infertility clinic and radiology centre based in Auckland, New Zealand.
POPULATION: The first cohort of 100 New Zealand women with infertility to undergo lipiodol flushing as an innovative fertility treatment.
METHODS: Women received lipiodol flushing performed by a hysterosalpingogram technique and were followed up at 6 months.
MAIN OUTCOME MEASURES: Clinical pregnancy at 6 months post-treatment; and live birth or ongoing pregnancy.
RESULTS: The overall pregnancy rate was 30% and the live birth or ongoing pregnancy rate 27%. For women under 40 years old, a 32% pregnancy rate and a 25% live birth or ongoing pregnancy rate were seen in women with unexplained infertility, and a 50% pregnancy rate and a 47% live birth or ongoing pregnancy rate were seen in women with endometriosis. Of women aged 40 years and older, the pregnancy rate was 13% and the live birth or ongoing pregnancy rate was 13%. The pregnancy rates included those occurring after additional interventions, such as intrauterine insemination and in vitro fertilisation, accounting for 12 of the 30 pregnancies. There were no treatment complications.
CONCLUSION: This study provides further evidence of the efficacy and safety of lipiodol flushing fertility treatment.