Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
Nodule size significantly affects the diagnostic value of chinese thyroid imaging reporting and data system: a multi-center retrospective study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Huang Hu, Gao Qi, Li Hong-Jian, Li Qi-Yuan, Li Wei-Min
Аннотация
PURPOSE: This study aimed to investigate the influence of thyroid nodule size on the diagnostic efficacy of the Chinese thyroid imaging reporting and data system (C-TIRADS).
PATIENTS AND METHODS: This retrospective study included pathologically confirmed thyroid nodules categorized into ≤ 10 mm and > 10 mm groups. The ultrasound characteristics of these nodules were evaluated, and C-TIRADS scoring and classification were performed. Receiver operating characteristic (ROC) curves were generated to ascertain optimal threshold values for scoring and classification in both groups. Subsequently, the diagnostic accuracies of C-TIRADS for thyroid nodules in the two groups were compared.
RESULTS: The ≤ 10 mm group included 237 benign, 1 low-risk, and 1,376 malignant nodules. The > 10 mm group included 499 benign, 13 low-risk, and 349 malignant nodules. The Mann-Whitney U test results revealed that scores for malignant thyroid nodules were significantly ˃ those for benign nodules in both groups. The ROC curves (AUC) for C-TIRADS scoring and classification in the ≤ 10 mm group were 0.707 and 0.684, respectively, with optimal threshold values of > 2 points and > C-TR 4B. In the > 10 mm group, AUCs for C-TIRADS scoring and classification were 0.927 and 0.922, respectively, with optimal threshold values of > 1 point and > C-TR of 4A. The > 10 mm group had greater specificity, negative predictive value (NPV) and accuracy than the ≤ 10 mm group, whereas the > 10 mm group had lower positive predictive value (PPV) than the ≤ 10 mm group at these optimal thresholds (all P-values < 0.001).
CONCLUSION: The diagnostic performance of C-TIRADS scoring and classification was significantly lower for thyroid nodules with a diameter of ≤ 10 mm than for those with a diameter of > 10 mm.
PATIENTS AND METHODS: This retrospective study included pathologically confirmed thyroid nodules categorized into ≤ 10 mm and > 10 mm groups. The ultrasound characteristics of these nodules were evaluated, and C-TIRADS scoring and classification were performed. Receiver operating characteristic (ROC) curves were generated to ascertain optimal threshold values for scoring and classification in both groups. Subsequently, the diagnostic accuracies of C-TIRADS for thyroid nodules in the two groups were compared.
RESULTS: The ≤ 10 mm group included 237 benign, 1 low-risk, and 1,376 malignant nodules. The > 10 mm group included 499 benign, 13 low-risk, and 349 malignant nodules. The Mann-Whitney U test results revealed that scores for malignant thyroid nodules were significantly ˃ those for benign nodules in both groups. The ROC curves (AUC) for C-TIRADS scoring and classification in the ≤ 10 mm group were 0.707 and 0.684, respectively, with optimal threshold values of > 2 points and > C-TR 4B. In the > 10 mm group, AUCs for C-TIRADS scoring and classification were 0.927 and 0.922, respectively, with optimal threshold values of > 1 point and > C-TR of 4A. The > 10 mm group had greater specificity, negative predictive value (NPV) and accuracy than the ≤ 10 mm group, whereas the > 10 mm group had lower positive predictive value (PPV) than the ≤ 10 mm group at these optimal thresholds (all P-values < 0.001).
CONCLUSION: The diagnostic performance of C-TIRADS scoring and classification was significantly lower for thyroid nodules with a diameter of ≤ 10 mm than for those with a diameter of > 10 mm.