Parkinson's Disease Motor Subtypes Change with the Progression of the Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up.
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Santos García Diego, Canfield Hector, de Deus Fonticoba Teresa, Cores Bartolomé Carlos, Naya Ríos Lucía, García Roca Lucía, Martínez Miró Cristina, Jesús Silvia, Aguilar Miquel, Pastor Pau, Cosgaya Marina, García Caldentey Juan, Caballol Nuria, Legarda Inés, Hernández Vara Jorge, Cabo Iria, López Manzanares Lydia, González Aramburu Isabel, Ávila Rivera María A, Gómez Mayordomo Víctor, Nogueira Víctor, Puente Víctor, Dotor Julio, Borrué Carmen, Solano Vila Berta, Álvarez Sauco María, Vela Lydia, Escalante Sonia, Cubo Esther, Carrillo Padilla Francisco, Martínez Castrillo Juan C, Sánchez Alonso Pilar, Alonso Losada Maria G, López Ariztegui Nuria, Gastón Itziar, Kulisevsky Jaime, Blázquez Estrada Marta, Seijo Manuel, Rúiz Martínez Javier, Valero Caridad, Kurtis Mónica, de Fábregues Oriol, González Ardura Jessica, Alonso Redondo Ruben, Ordás Carlos, López Díaz Luis M, McAfee Darrian, Martinez-Martin Pablo, Mir Pablo, COPPADIS Study Group
Аннотация
OBJECTIVE: Our aim was to analyze how the MP changed over time and to identify factors associated with the changes in PD patients from a multicenter Spanish PD cohort.
METHODS: PD patients who were recruited from January-2016 to November-2017 (baseline visit; V0) and evaluated again at a 2-year±30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this study.MP was calculated at both visits based on Jankovic classification in TD (tremor dominant), IND (indeterminate), or PIGD (postural instability and gait difficulty). Sociodemographic and clinical data were collected, including serum biomarkers.
RESULTS: Five hundred eleven patients (62.57±8.59 years old; 59.2%males) were included in the study. At V0, MP was: 47.4%(242/511) TD; 36.6%(187/511) PIGD; 16%(82/511) IND. Up to 38%(194/511) of the patients changed their phenotype from V0 to V2, being the most frequent from TD to IND (8.4%) and from TD to PIGD (6.7%). A worse cognitive status (OR = 0.966) and less autonomy for activities of daily living (OR = 0.937) at V0 and a greater increase in the globalNMS burden (OR = 1.011) from V0 to V2 were associated with changing from TD to another phenotype after 2-year follow-up.
CONCLUSION: The MP in PD can change over time. With disease progression, the percentage of cases with non-tremoric MP increases. PD patients who changed from TD to postural instability and gait difficulty increased NMS burden significantly.