Revista brasileira de enfermagem · 2018
Diagnostic validity of biomarkers in Parkinson's Disease: systematic review and meta-analysis.
СтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод в очереди
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Costa Maria Fernanda Baeta Neves Alonso da, Reisdorfer Emilene, Kempfer Silvana Silveira, Fernandes Gisele Cristina Manfrini, Porporatti André Luís, Canto Graziela De Luca
Аннотация
OBJECTIVE: To identify biomarkers for Parkinson's disease, cerebrospinal fluid, blood, saliva, and urine.
METHOD: The studies were collected from the Cochrane, LILACS, PubMed, SCOPUS, WEB OF SCIENCE, OpenGrey, ProQuest and Google Scholar databases starting from May 3, 2016 and updated on March 20, 2017. Twenty-two studies were evaluated, by the Quality Assessment Tool for Diagnostic Accuracy Studies and Review Manager 5.3.
RESULTS: Evidence shows that serum antibodies can be used as highly specific and accurate biomarkers for the diagnosis of Parkinson's disease at the outset. Biomarkers in the cerebrospinal fluid are related to increased motor severity, postural instability, gait abnormality, and cognitive impairment.
CONCLUSION: Serum and cerebrospinal antibodies can be used as diagnostic biomarkers at the onset of the disease.
METHOD: The studies were collected from the Cochrane, LILACS, PubMed, SCOPUS, WEB OF SCIENCE, OpenGrey, ProQuest and Google Scholar databases starting from May 3, 2016 and updated on March 20, 2017. Twenty-two studies were evaluated, by the Quality Assessment Tool for Diagnostic Accuracy Studies and Review Manager 5.3.
RESULTS: Evidence shows that serum antibodies can be used as highly specific and accurate biomarkers for the diagnosis of Parkinson's disease at the outset. Biomarkers in the cerebrospinal fluid are related to increased motor severity, postural instability, gait abnormality, and cognitive impairment.
CONCLUSION: Serum and cerebrospinal antibodies can be used as diagnostic biomarkers at the onset of the disease.