International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2015
Meta-analysis of oral contraceptive use and risks of all-cause and cause-specific death.
СтатьяМетаанализОбзорНазвание и аннотация: Перевод в очереди
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Zhong Guo-Chao, Cheng Jia-Hao, Xu Xiang-Long, Wang Kang
Аннотация
BACKGROUND: Whether ever use of oral contraceptives (OCs) is associated with mortality remains unclear.
OBJECTIVES: To evaluate the association between ever use of OCs and mortality.
SEARCH STRATEGY: On November 2, 2014, PubMed and Embase were searched for human studies, using the terms "contraceptive," "contraceptives," "death," and "mortality."
SELECTION CRITERIA: Prospective cohort studies were included that provided risk estimates on OC use and mortality, and were reported in English or Chinese.
DATA COLLECTION AND ANALYSIS: A random-effects model was used to pool data. Random-effects meta-regression was used to determine whether duration of OC use and time since last OC use were associated with mortality.
MAIN RESULTS: Nine studies were included. Ever use of OCs was not associated with mortality from all causes (hazard ratio [HR] 0.94; 95% CI 0.87-1.02) or breast cancer (HR 1.00; 95% CI 0.95-1.06). Neither the duration of OC use nor the time since last OC use was associated with all-cause or breast cancer mortality. In an analysis of a small number of studies, ever users were at decreased risk of mortality from ovarian cancer (HR 0.58; 95% CI 0.35-0.94).
CONCLUSIONS: There is no significant association between ever use of OCs and mortality from all causes or breast cancer.
OBJECTIVES: To evaluate the association between ever use of OCs and mortality.
SEARCH STRATEGY: On November 2, 2014, PubMed and Embase were searched for human studies, using the terms "contraceptive," "contraceptives," "death," and "mortality."
SELECTION CRITERIA: Prospective cohort studies were included that provided risk estimates on OC use and mortality, and were reported in English or Chinese.
DATA COLLECTION AND ANALYSIS: A random-effects model was used to pool data. Random-effects meta-regression was used to determine whether duration of OC use and time since last OC use were associated with mortality.
MAIN RESULTS: Nine studies were included. Ever use of OCs was not associated with mortality from all causes (hazard ratio [HR] 0.94; 95% CI 0.87-1.02) or breast cancer (HR 1.00; 95% CI 0.95-1.06). Neither the duration of OC use nor the time since last OC use was associated with all-cause or breast cancer mortality. In an analysis of a small number of studies, ever users were at decreased risk of mortality from ovarian cancer (HR 0.58; 95% CI 0.35-0.94).
CONCLUSIONS: There is no significant association between ever use of OCs and mortality from all causes or breast cancer.