Exploring The Potential of The Intensive Care Infection Score in Antimicrobial Stewardship: A Case Report.

Improved biomarkers are needed for infection diagnosis, reducing sepsis risk and guiding antibiotic therapy. Intensive Care Infection Score (ICIS) reflects the early innate immune response to infection, independent of systemic inflammation. Three cases were selected where ICIS was evaluated retrospectively, highlighting the potential of ICIS in antimicrobial stewardship (AMS): (1) ICIS suggested a possible secondary infection, (2) it portends a poor initial response to antibiotics, prompting the need for a change in therapy, and (3) it implies a noninfectious condition, thereby potentially avoiding unnecessary antibiotics. This case series underscores the potential of ICIS for clinical application, particularly in supporting AMS.