BJOG : an international journal of obstetrics and gynaecology · 2000
The effect of smoking on pre-eclampsia in twin pregnancy.
СтатьяTwin StudyНазвание и аннотация: Перевод в очереди
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Martin C L, Hall M H, Campbell D M
Аннотация
OBJECTIVE: To assess the effect of smoking on the incidence of pre-eclampsia and on perinatal outcome in twin pregnancy.
DESIGN: Retrospective study using Aberdeen Maternity and Neonatal Databank.
SETTING: Grampian, Orkney and Shetland.
POPULATION: All 1,575 twin pregnancies delivered in the years 1969-1971 and 1976-1997 (when smoking data were available).
METHODS: In all twin pregnancies the effects of smoking on pre-eclampsia were analysed by parity and gestation at delivery. The effect of smoking upon late miscarriage and perinatal outcome was analysed without subdivision.
MAIN OUTCOME MEASURES: Pre-eclampsia and perinatal outcome.
RESULTS: Primiparae had significantly higher rates of pre-eclampsia than multiparae and were delivered significantly earlier. The incidence of pre-eclampsia in smokers was significantly lower only in multiparae. Length of gestation was significantly shorter in multiparous smokers. The effect of smoking on pre-eclampsia appeared to be direct in multiparae but possibly indirect in primiparae (by causing earlier delivery). Smokers had a higher late miscarriage rate than nonsmokers.
CONCLUSIONS: In twin pregnancy the apparent protective effect of smoking against pre-eclampsia is significant only in multiparae, suggesting that in primiparae the smoking effect is overwhelmed by the other reasons for the development of pre-eclampsia. Smoking in twin pregnancy is not recommended due to the worse fetal outcome rates.
DESIGN: Retrospective study using Aberdeen Maternity and Neonatal Databank.
SETTING: Grampian, Orkney and Shetland.
POPULATION: All 1,575 twin pregnancies delivered in the years 1969-1971 and 1976-1997 (when smoking data were available).
METHODS: In all twin pregnancies the effects of smoking on pre-eclampsia were analysed by parity and gestation at delivery. The effect of smoking upon late miscarriage and perinatal outcome was analysed without subdivision.
MAIN OUTCOME MEASURES: Pre-eclampsia and perinatal outcome.
RESULTS: Primiparae had significantly higher rates of pre-eclampsia than multiparae and were delivered significantly earlier. The incidence of pre-eclampsia in smokers was significantly lower only in multiparae. Length of gestation was significantly shorter in multiparous smokers. The effect of smoking on pre-eclampsia appeared to be direct in multiparae but possibly indirect in primiparae (by causing earlier delivery). Smokers had a higher late miscarriage rate than nonsmokers.
CONCLUSIONS: In twin pregnancy the apparent protective effect of smoking against pre-eclampsia is significant only in multiparae, suggesting that in primiparae the smoking effect is overwhelmed by the other reasons for the development of pre-eclampsia. Smoking in twin pregnancy is not recommended due to the worse fetal outcome rates.