Ghana medical journal · 2024
Sex hormone-binding globulin is a valuable diagnostic indicator of gestational diabetes mellitus.
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Bruno Basil, Blessing Myke-Mbata K, Izuchukwu Mba N, Terry Gbaa T, Faeren Dogoh
Аннотация
OBJECTIVE: To assess the performance of the Sex Hormone-Binding Globulin (SHBG) assay as a diagnostic indicator of Gestational Diabetes Mellitus (GDM) in the study population.
DESIGN: Analytical cross-sectional study.
SETTING: Hospital-based, Benue State University Teaching Hospital (BSUTH), Makurdi, Nigeria.
PARTICIPANTS: Women with singleton pregnancies at 24 to 28 weeks gestational age attending Antenatal care at BSUTH, Makurdi.
INTERVENTION: Serum SHBG levels were assayed by ELISA during a diagnostic 75-gram Oral Glucose Tolerance Test (OGTT) for assessment of GDM in the cohort of consecutively selected participants who met the inclusion criteria.
MAIN OUTCOME MEASURES: Serum levels of SHBG and presence of GDM in the participants.
RESULT: Serum SHBG was significantly negatively correlated (rpb = - 0.534, p-value < 0.001) with the presence of GDM. It had an area under the ROC curve of 0.897 (95% Confidence Interval = 0.858-0.935; p-value < 0.001). A cut-off value of 452.0 nmol/L indicative of GDM had a diagnostic odds ratio of 21.4 in the study population.
CONCLUSION: SHBG is a valuable diagnostic indicator for GDM in the study population.
FUNDING: None declared.
DESIGN: Analytical cross-sectional study.
SETTING: Hospital-based, Benue State University Teaching Hospital (BSUTH), Makurdi, Nigeria.
PARTICIPANTS: Women with singleton pregnancies at 24 to 28 weeks gestational age attending Antenatal care at BSUTH, Makurdi.
INTERVENTION: Serum SHBG levels were assayed by ELISA during a diagnostic 75-gram Oral Glucose Tolerance Test (OGTT) for assessment of GDM in the cohort of consecutively selected participants who met the inclusion criteria.
MAIN OUTCOME MEASURES: Serum levels of SHBG and presence of GDM in the participants.
RESULT: Serum SHBG was significantly negatively correlated (rpb = - 0.534, p-value < 0.001) with the presence of GDM. It had an area under the ROC curve of 0.897 (95% Confidence Interval = 0.858-0.935; p-value < 0.001). A cut-off value of 452.0 nmol/L indicative of GDM had a diagnostic odds ratio of 21.4 in the study population.
CONCLUSION: SHBG is a valuable diagnostic indicator for GDM in the study population.
FUNDING: None declared.