Microvascular research · 2024
Robust analysis of microcirculatory flowmotion during post-occlusive reactive hyperemia.
СтатьяВалидационное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Hultman Martin, Richter Freya, Larsson Marcus, Strömberg Tomas, Iredahl Fredrik, Fredriksson Ingemar
Аннотация
BACKGROUND: Flowmotion analysis of the microcirculatory blood flow is a method to extract information about the vessel regulatory function. It has previously shown promise when applied to measurements during a post-occlusive reactive hyperemia. However, the reperfusion peak and the following monotonic decline introduces false low frequencies that should not be interpreted as rhythmic vasomotion effect.
AIM: To develop and validate a robust method for flowmotion analysis of post-occlusive reactive hyperemia signals.
METHOD: The occlusion-induced reperfusion response contains a typical rapid increase followed by a monotonic decline to baseline. A mathematical model is proposed to detrend this transient part of the signal to enable further flowmotion analysis. The model is validated in 96 measurements on healthy volunteers.
RESULTS: Applying the proposed model corrects the flowmotion signal without adding any substantial new false flowmotion components.
CONCLUSION: Future studies should use the proposed method or equivalent when analyzing flowmotion during post-occlusive reactive hyperemia to ensure valid results.
AIM: To develop and validate a robust method for flowmotion analysis of post-occlusive reactive hyperemia signals.
METHOD: The occlusion-induced reperfusion response contains a typical rapid increase followed by a monotonic decline to baseline. A mathematical model is proposed to detrend this transient part of the signal to enable further flowmotion analysis. The model is validated in 96 measurements on healthy volunteers.
RESULTS: Applying the proposed model corrects the flowmotion signal without adding any substantial new false flowmotion components.
CONCLUSION: Future studies should use the proposed method or equivalent when analyzing flowmotion during post-occlusive reactive hyperemia to ensure valid results.