The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2014
ß-hCG and prediction of therapeutic success in ectopic pregnancies treated with methotrexate, results from a prospective observational study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Orozco Esteban Mauricio, Sánchez-Durán Maria Angeles, Bello-Muñoz Juan Carlos, Sagalá Juan, Carreras Elena, Roura Lluis Cabero
Аннотация
OBJECTIVE: To evaluate the diagnostic accuracy of different beta-human chorionic gonadotrophin (ß-hCG) levels measurement, for predicting success of medical treatment in cases diagnosed as tubal ectopic pregnancy (TEP).
DESIGN: Five-year prospective observational study.
SETTING: Prenatal Diagnosis Unit, Vall d'Hebron University Hospital - Barcelona.
PATIENTS: TEP cases fulfilling criteria for medical treatment with Methotrexate.
INTERVENTIONS: ß-hCG levels were measured on d 0, 4 and 7 of treatment. Results were compared by non-parametrical tests. A ROC curve was plotted to define cut-off points. Diagnostic accuracy of the different measurements was evaluated.
MAIN OUTCOME MEASURE: Failure of treatment defined as need for surgical treatment or persistence of high ß-HCG levels despite treatment.
RESULTS: 126 women were diagnosed as TEP, eligible for medical treatment. There were no differences in parity, age, previous TEP, or adnexal mass size. Success rate was 88%. ß-HCG decreased significantly more, between days 0-7 and 4-7, in the successful cases. LR for success prediction was 6.2 and 7.8 for ß-HCG levels at days 4 and 7 respectively, 4.02 and 2.47 for decrement between days 0-7 (25%) and 4-7 (20%), respectively.
CONCLUSION: ß-hCG cutoff values have a potential for predicting a successful medical treatment of TEP.
DESIGN: Five-year prospective observational study.
SETTING: Prenatal Diagnosis Unit, Vall d'Hebron University Hospital - Barcelona.
PATIENTS: TEP cases fulfilling criteria for medical treatment with Methotrexate.
INTERVENTIONS: ß-hCG levels were measured on d 0, 4 and 7 of treatment. Results were compared by non-parametrical tests. A ROC curve was plotted to define cut-off points. Diagnostic accuracy of the different measurements was evaluated.
MAIN OUTCOME MEASURE: Failure of treatment defined as need for surgical treatment or persistence of high ß-HCG levels despite treatment.
RESULTS: 126 women were diagnosed as TEP, eligible for medical treatment. There were no differences in parity, age, previous TEP, or adnexal mass size. Success rate was 88%. ß-HCG decreased significantly more, between days 0-7 and 4-7, in the successful cases. LR for success prediction was 6.2 and 7.8 for ß-HCG levels at days 4 and 7 respectively, 4.02 and 2.47 for decrement between days 0-7 (25%) and 4-7 (20%), respectively.
CONCLUSION: ß-hCG cutoff values have a potential for predicting a successful medical treatment of TEP.